Nettsider med emneord «brain research»
Wireless solutions in brain research have so far been limited
by low data transmission, short recording time or bulky batteries and devices. Our objective is to develop a wireless Micro Electro-Optical system (MEMS) device for long-term, recording and manipulations of brain activity in rodents.
This is a project in collaboration with the Hafting-Fyhn group at the institute for biological sciences (IBV) at the biology department. The goal is to construct a neural recording device that records neural signals from a rat for several hours form brain electrodes onto a memory card. The system needs to be compact and light enough to be carried by the animal.
This is a project in collaboration with the Hafting-Fyhn group at the institute for biological sciences (IBV) at the biology department. The goal is to construct a neural recording device that records neural signals from a rat for several hours form brain electrodes onto a memory card. The system needs to be compact and light enough to be carried by the animal. There are two variants on how to approach this system: either 1) a fully integrated system (except for the memory card) on an integrated circuit or 2) as system built from a commercial neural amplifier and analog to digital converter chip (e.g. from Intan AS) and an FPGA that controls this chip and interfaces it with a memory card.
We show that systemic injections of PHP.eB AAVs to express GECIs is a highly promising technique for imaging neural activity and circumvent the need for transgenic GECI expressing mouse lines. We also establish the use of novel soma-targeted GECIs that outperform current Ca2+ indicators using both systemic and local virus injections.