Dag Erlend Olberg

• Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed Mohammad; Klaveness, Jo & Olberg, Dag Erlend (2023). Synthesis and preclinical evaluation of a selective MET kinase positron emission tomography tracer. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 66(14), p. 452–460. doi: 10.1002/jlcr.4066.
• Hoareau, Raphaël; Bach-Gansmo, Tore; Cumming, Paul & Olberg, Dag Erlend (2022). A new automated and putatively versatile synthesis of the PSMA-ligand derivative [18F]DCFPyL using the FASTlabTM synthesizer. EJNMMI Radiopharmacy and Chemistry. ISSN 2365-421X. 7(1). doi: 10.1186/s41181-022-00157-0.
• Lien, Vegard Torp; Celen, Sofie; Nuruddin, Syed; Attili, Bala; Doumont, Gilles & Van Simaeys, Gaetan [Show all 9 contributors for this article] (2021). Preclinical evaluation of [18F]cabozantinib as a PET imaging agent in a prostate cancer mouse model. Nuclear Medicine and Biology. ISSN 0969-8051. 93, p. 74–80. doi: 10.1016/j.nucmedbio.2020.12.002.
• Syvänen, Stina; Fang, Xiaotian; Faresjö, Rebecca; Rokka, Johanna; Lannfelt, Lars & Olberg, Dag Erlend [Show all 8 contributors for this article] (2020). Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain. ACS Chemical Neuroscience. ISSN 1948-7193. 11(24), p. 4460–4468. doi: 10.1021/acschemneuro.0c00652.
• Cumming, Paul; Marton, János; Lilius, Tuomas O.; Olberg, Dag Erlend & Rominger, Axel (2019). A survey of molecular imaging of opioid receptors. Molecules. ISSN 1431-5157. 24:4190(22), p. 1–35. doi: 10.3390/molecules24224190.
• Aasen, Synnøve Nymark; Espedal, Heidi; Holte, Christopher Florian; Keunen, Olivier; Karlsen, Tine Veronica & Tenstad, Olav [Show all 18 contributors for this article] (2019). Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier. Molecular Cancer Therapeutics. ISSN 1535-7163. 18(11), p. 2171–2181. doi: 10.1158/1535-7163.MCT-19-0160.
• Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend & Waaler, Jo [Show all 7 contributors for this article] (2019). Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. ISSN 2046-2069. 9(63), p. 37092–37100. doi: 10.1039/c9ra08954c.
• Lien, Vegard Torp; Olberg, Dag Erlend; Hagelin, Gunnar & Klaveness, Jo (2019). Synthesis and antiproliferative evaluation of novel N‑arylquinolones. Monatshefte für Chemie. ISSN 0026-9247. 150(11), p. 1947–1957. doi: 10.1007/s00706-019-02504-5.
• Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari & Klaveness, Jo (2019). Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors. Archiv der Pharmazie. ISSN 0365-6233. 352(9). doi: 10.1002/ardp.201900101. Full text in Research Archive
• Tungen, Jørn Eivind; Aursnes, Marius; Ramon, Sesquile; Colas, Romain A.; Serhan, Charles Nicholas & Olberg, Dag Erlend [Show all 9 contributors for this article] (2018). Synthesis of Protectin D1 Analogs: Novel Pro-resolution and Radiotracer Agents. Organic and biomolecular chemistry. ISSN 1477-0520. 16, p. 6818–6823. doi: 10.1039/c8ob01232f.
• Lien, Vegard Torp; Grønås, Kari; Olberg, Dag Erlend & Klaveness, Jo (2018). Onkologiske legemidler: Utviklingen fra konvensjonelle cytostatika til nib-er, mab-er og andre nyvinninger. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 8, p. 24–29.
• Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri & Klaveness, Jo (2017). Recent development of non-peptide GnRH antagonists. Molecules. ISSN 1431-5157. 22:2188(12), p. 1–25. doi: 10.3390/molecules22122188. Full text in Research Archive
• Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 61(1), p. 11–17. doi: 10.1002/jlcr.3564.
• Lien, Vegard Torp; Olberg, Dag Erlend; Klaveness, Jo & Görbitz, Carl Henrik (2017). Crystal structure of 6,7-dimeth­­oxy-1-(4-nitro­phen­yl)quinolin-4(1H)-one: a mol­ecular scaffold for potential tubulin polymerization inhibitors. Acta Crystallographica Section E: Crystallographic Communications. ISSN 2056-9890. 73, p. 441–444. doi: 10.1107/S2056989017002948.
• Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav & Marton, Janos [Show all 10 contributors for this article] (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery. ISSN 1570-1808. 14(7), p. 787–797. doi: 10.2174/1570180813666161101152943. Show summary

  Histone deacetylases (HDACs) emerged as important epigenetic regulators of gene expression. In order to identify potential positron emission tomography (PET) tracers for imaging HDACs, we evaluated in vitro and in cellulo activities of some compounds that were reported as potent HDAC2-selective inhibitors. We observed marked differences between reported activity values and the values obtained in our assays for some of the compounds. To understand the structural basis of the activity of some of these inhibitors, we also performed molecular docking studies to understand their interaction patterns and binding modes with HDAC2. We observed the low affinity compounds 4, 6 and 7 did not showed equal number of key π-π interactions and hydrogen bonding when compared to high affinity compounds, and could be the possible reason for poor inhibition as reflected in in vitro assays. These preliminary experimental and computational results will help to interpret the HDAC affinity values of these key compounds with caution.

• Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Show all 9 contributors for this article] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), p. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
• Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Show all 10 contributors for this article] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, p. 708–714. doi: 10.1039/c4md00486h.
• Cumming, Robin C.; Olberg, Dag Erlend & Sutcliffe, Julie L. (2014). Rapid 18F-radiolabeling of peptides from [18F] fluoride using a single microfluidics device. RSC Advances. ISSN 2046-2069. 4(90), p. 49529–49534. doi: 10.1039/c4ra10520f.
• Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), p. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
• Olberg, Dag Erlend; Hagen, Inger A.; Hagen, Anniken & Haraldsen, Ira Hebold (2012). Peptider for positronemisjonstomografi (PET). Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 120(1), p. 20–24.
• Hjelstuen, ole kristian; Svadberg, Anders; Olberg, Dag Erlend & Rosser, Mark (2011). Standardization of fluorine-18 manufacturing processes: New scientific challenges for PET. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 78(3), p. 307–313. doi: 10.1016/j.ejpb.2011.01.002.
• Wojniusz, Slawomir; Vögele, Claus; Ropstad, Erik; Evans, Neil; Robinson, Jane & Sütterlin, Stefan [Show all 11 contributors for this article] (2011). Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep. Hormones and Behavior. ISSN 0018-506X. 59, p. 22–27. doi: 10.1016/j.yhbeh.2010.09.010. Show summary

  In mammals, sex specialization is reflected by differences in brain anatomy and function. Measurable differences are documented in reproductive behavior, cognition, and emotion. We hypothesized that gonadotropin-releasing hormone (GnRH) plays a crucial role in controlling the extent of the brain's sex specificity and that changes in GnRH action during critical periods of brain development, such as puberty, will result in altered sex-specific behavioral and physiological patterns. We blocked puberty in half of the 48 same-sex Scottish mule Texel cross sheep twins with GnRH analog (GnRHa) goserelin acetate every 3weeks, beginning just before puberty. To determine the effects of GnRHa treatment on sex-specific behavior and emotion regulation in different social contexts, we employed the food acquisition task (FAT) and measurement of heart rate variability (HRV). ANOVA revealed significant sex and sex×treatment interaction effects, suggesting that treated males were more likely to leave their companions to acquire food than untreated, while the opposite effect was observed in females. Concordant results were seen in HRV; treated males displayed higher HRV than untreated, while the reverse pattern was found in females, as shown by significant sex and sex×treatment interaction effects. We conclude that long-term prepubertal GnRHa treatment significantly affected sex-specific brain development, which impacted emotion and behavior regulation in sheep. These results suggest that GnRH is a modulator of cognitive function in the developing brain and that the sexes are differentially affected by GnRH modulation.

• Olberg, Dag Erlend; Cuthbertson, Alan; Solbakken, Magne; Arukwe, Joseph M; Qu, Hong & Kristian, Alexandr [Show all 8 contributors for this article] (2010). Radiosynthesis and Biodistribution of a Prosthetic Group (F-18-FENMA) Conjugated to Cyclic RGD Peptides. Bioconjugate chemistry. ISSN 1043-1802. 21(12), p. 2297–2304. doi: 10.1021/bc1003229.
• Olberg, Dag Erlend & Hjelstuen, ole kristian (2010). Labeling Strategies of Peptides with F-18 for Positron Emission Tomography. Current Topics in Medicinal Chemistry. ISSN 1568-0266. 10(16), p. 1669–1679.
• Olberg, Dag Erlend; Arukwe, Joseph M; Grace, David; Hjelstuen, ole kristian; Solbakken, Magne & Kindberg, Grete M. [Show all 7 contributors for this article] (2010). One Step Radiosynthesis of 6-[F-18]Fluoronicotinic Acid 2,3,5,6-Tetrafluorophenyl Ester ([F-18]F-Py-TFP): A New Prosthetic Group for Efficient Labeling of Biomolecules with Fluorine-18. Journal of Medicinal Chemistry. ISSN 0022-2623. 53(4), p. 1732–1740. doi: 10.1021/jm9015813.
• Høyem, Sverre; Bruheim, Skjalg; Mælandsmo, Gunhild M; Standal, Marius; Olberg, Dag Erlend & Brudeli, Bjarne [Show all 9 contributors for this article] (2009). Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats. European Journal of Medicinal Chemistry. ISSN 0223-5234. 44(10), p. 3874–3879. doi: 10.1016/j.ejmech.2009.04.008.
• Høyem, Sverre; Bruheim, Skjalg; Mælandsmo, Gunhild; Standal, Marius; Olberg, Dag Erlend & Brudeli, Bjarne [Show all 9 contributors for this article] (2009). Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats. European Journal of Medicinal Chemistry. ISSN 0223-5234. 44, p. 3874–3879.
• Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph M; Dyrstad, Knut & Cuthbertson, Alan (2009). Site-specific addition of an F-18-N-methylaminooxy-containing prosthetic group to a vinylsulfone modified peptide. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52(13-14), p. 571–575. doi: 10.1002/Jlcr.1686.
• Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph; Karlsen, Hege & Cuthbertson, Alan (2008). A novel prosthetic group for site-selective labeling of peptides for positron emission tomography. Bioconjugate chemistry. ISSN 1043-1802. 19(6), p. 1301–1308. doi: 10.1021/bc800007h.

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• Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Krauss, Stefan Johannes Karl & Olberg, Dag Erlend [Show all 8 contributors for this article] (2020). Erratum: Towards dual inhibitors of the MET kinase and WNT signaling pathway; Design, synthesis and biological evaluation (RSC Advances (2019) 9 (37092-37100) DOI: 10.1039/D0RA90007A). RSC Advances. ISSN 2046-2069. 10(9). doi: 10.1039/d0ra90007a.
• Lien, Vegard Torp; Hauge, Emily; Nuruddin, Syed; Klaveness, Jo & Olberg, Dag Erlend (2019). Synthesis and preclinical evaluation of a selective c-Met PET tracer.
• Lien, Vegard Torp; Klaveness, Jo & Olberg, Dag Erlend (2017). One-step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c-Met.
• Cumming, Robin; Olberg, Dag Erlend & Sutcliffe, Julie (2013). Rapid high-yielding radiosynthesis of [F-18] F-Py-TFP using a microfluidic system. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56, p. S477–S477.
• Olberg, Dag Erlend; Haraldsen, Ira Hebold & Sutcliffe, J. (2013). Synthesis and evaluation of small molecular [F-18]labeled gonadotropin-releasing hormone (GnRH) receptor antagonist as potential PET imaging agents for GnRH receptor expression in CNS. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 56, p. S333–S333.
• Olberg, Dag Erlend; Arukwe, J; Solbakken, M; Cuthbertson, A; Qu, H & Kristian, A [Show all 7 contributors for this article] (2009). RADIOSYNTHESIS AND BIODISTRIBUTION OF CYCLIC RGD PEPTIDES CONJUGATED WITH A NOVEL [18F] FLUORINATED N-METHYLAMINOOXY CONTAINING PROSTHETIC GROUP. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, p. S32–S32.
• Olberg, Dag Erlend; Arukwe, J; Grace, D & Hjelstuen, ole kristian (2009). 2-TRIMETHYLAMMONIUM NICOTINIC ACID TFP-ESTER: A NOVEL PYRIDINE BASED SYSTEM FOR THE ONE-STEP LABELLING OF BIOMOLECULES WITH FLUORINE-18. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, p. S160–S160.
• Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, M; Arukwe, J; Dyrstad, K & Cuthbertson, A (2009). SITE-SPECIFIC ADDITION OF AN 18F-N-METHYLAMINOOXY CONTAINING PROSTHETIC GROUP TO A VINYLSULFONE MODIFIED PEPTIDE. Journal of labelled compounds & radiopharmaceuticals. ISSN 0362-4803. 52, p. S161–S161.
• Olberg, Dag Erlend; Arukwe, Joseph M; Grace, D & Hjelstuen, ole kristian (2009). 2-Trimethylammonium nicotinic acid TFP-ester: A novel pyridine based system for the one-step labelling of biomolecules with fluorine-18.
• Olberg, Dag Erlend; Hjelstuen, ole kristian; Solbakken, Magne; Arukwe, Joseph M; Dyrstad, Knut & Cuthbertson, Alan (2009). Site-specific addition of an 18F-N-Methylaminooxy containing prosthetic group to a vinylsulfone modified peptide.
• Hauge, Emily; Olberg, Dag Erlend; Lien, Vegard Torp & Klaveness, Jo (2018). New 18F-labelled Selective c-Met Inhibitor; Synthesis, 18F-radiolabelling and Binding Affinity Studies of a New Selective c-Met Inhibitor for use in Positron Emission Tomography . 7Letras.
• Olberg, Dag Erlend (2009). Novel (18F)Fluorinated prosthetic groups for the labelling of peptides for positron emission tomography (PET). Tromsprodukt.

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