Kari Tvete Inngjerdingen

• Zhang, Chao-Wen; Zou, Yuanfeng; Zou, Yun; JiZe, Xiao-Ping; Li, Cen-Yu & Fu, Yu-Ping [Show all 18 contributors for this article] (2024). Ultrasonic-assisted extraction of polysaccharide from Paeoniae Radix alba: Extraction optimization, structural characterization and antioxidant mechanism in vitro. International Journal of Biological Macromolecules. ISSN 0141-8130. 268. doi: 10.1016/j.ijbiomac.2024.131816.
• Wold, Christian Winther; Christopoulos, Panagiotis; Arias, Maykel; Dzovor, Deborah Elikplim; Øynebråten, Inger & Corthay, Alexandre Benoit [Show all 7 contributors for this article] (2024). Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity. Communications Biology. ISSN 2399-3642. 7. doi: 10.1038/s42003-024-05853-y.
• Butt, Hussain Shakeel; Ulriksen, Emilie Steinbakk; Rise, Frode; Wangensteen, Helle; Duus, Jens Øllgaard & Inngjerdingen, Marit [Show all 7 contributors for this article] (2024). Structural elucidation of novel pro-inflammatory polysaccharides from Daphne mezereum L. Carbohydrate Polymers. ISSN 0144-8617. 324. doi: 10.1016/j.carbpol.2023.121554. Full text in Research Archive
• Fu, Yu-ping; Li, Cen-Yu; Zou, Yuanfeng; Peng, Xi; Paulsen, Berit Smestad & Wangensteen, Helle [Show all 7 contributors for this article] (2023). Bioactive polysaccharides in different plant parts of Aconitum carmichaelii. Journal of the Science of Food and Agriculture. ISSN 0022-5142. 104(2). doi: 10.1002/jsfa.12967. Full text in Research Archive
• Fu, Yu-ping; Malterud, Karl Egil; Hamre, Anne Grethe; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2023). Polysaccharides and Bioactive Phenolics from Aconitum septentrionale Roots. Chemistry and Biodiversity. ISSN 1612-1872. 20(8). doi: 10.1002/cbdv.202300161. Full text in Research Archive
• Zhang, Lin; Ulriksen, Emilie Steinbakk; Hoel, Håvard; Sandvik, Lene; Malterud, Karl Egil & Inngjerdingen, Kari Tvete [Show all 8 contributors for this article] (2023). Phytochemical characterization and anti-inflammatory activity of a water extract of Gentiana purpurea roots. Journal of Ethnopharmacology. ISSN 0378-8741. 301. doi: 10.1016/j.jep.2022.115818. Full text in Research Archive
• Fu, Yu-ping; Li, Cen-Yu; Peng, Xi; Wangensteen, Helle; Inngjerdingen, Kari Tvete & Zou, Yuan-Feng (2022). Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition. Biomedicine & Pharmacotherapy. ISSN 0753-3322. 155. doi: 10.1016/j.biopha.2022.113767. Full text in Research Archive
• Dénou, Adama; Togola, Adiaratou; Inngjerdingen, Kari Tvete; Moussavi, Nastaran; Rise, Frode & Zou, Yuanfeng [Show all 13 contributors for this article] (2022). Isolation, characterisation and complement fixation activity of acidic polysaccharides from Argemone mexicana used as antimalarials in Mali. Pharmaceutical Biology. ISSN 1388-0209. 60(1), p. 1278–1285. doi: 10.1080/13880209.2022.2089691. Full text in Research Archive
• Moussavi, Nastaran; Azizullah, Hasina; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2022). Immunomodulating polyphenols from Sideritis scardica. Journal of Functional Foods. ISSN 1756-4646. 96. doi: 10.1016/j.jff.2022.105197. Full text in Research Archive
• Fu, Yu-ping; Li, Cen-Yu; Peng, Xi; Zou, Yuan-Feng; Rise, Frode & Paulsen, Berit Smestad [Show all 8 contributors for this article] (2022). Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities. Carbohydrate Polymers. ISSN 0144-8617. 291. doi: 10.1016/j.carbpol.2022.119655. Full text in Research Archive
• Ulriksen, Emilie Steinbakk; Butt, Hussain Shakeel; Ohrvik, Ane; Blakeney, Rebecca Angelica; Kool, Anneleen & Wangensteen, Helle [Show all 8 contributors for this article] (2022). The discovery of novel immunomodulatory medicinal plants by combination of historical text reviews and immunological screening assays. Journal of Ethnopharmacology. ISSN 0378-8741. 296. doi: 10.1016/j.jep.2022.115402. Full text in Research Archive Show summary

  This study investigates the utilization of medicinal plants in Scandinavian folk medicine for treating diseases believed to involve the immune system. The methodology involves screening water extracts from medicinal plants that have been previously overlooked, aiming to identify potential new reservoirs of immunomodulatory compounds.

• Fu, Yuping; Zou, Yuan-Feng; Lei, Fei-Yi; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2022). Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots. Journal of Ethnopharmacology. ISSN 0378-8741. 291. doi: 10.1016/j.jep.2022.115148.
• Denou, Adama; Ahmed, Abubakar; Dafam, Dalen Gwatau; Ochala, Sunshine Ogwu; Omale, Simeon & Inngjerdingen, Kari Tvete [Show all 10 contributors for this article] (2020). Safety evaluation of polysaccharides isolated from the water extract of Argemone mexicana L. (Papaveraceae) in Drosophila melanogaster. Journal of Applied Pharmaceutical Science (JAPS). 10(2), p. 44–48. doi: 10.7324/JAPS.2020.102007.
• Wold, Christian Winther; Gerwick, William H.; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2020). Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity. Journal of Functional Foods. ISSN 1756-4646. 71. doi: 10.1016/j.jff.2020.104025.
• Zou, Yuanfeng; Zhang, Yan-Yun; Fu, Yu-Ping; Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad & Feng, Bin [Show all 17 contributors for this article] (2019). A Polysaccharide Isolated from Codonopsis pilosula with Immunomodulation Effects Both In Vitro and In Vivo. Molecules. ISSN 1431-5157. 24(20), p. 1–13. doi: 10.3390/molecules24203632.
• Denou, Adama; Togola, Adiaratou; Inngjerdingen, Kari Tvete; Zhang, Bing-Zhao; Ahmed, Abubakar & Dafam, Dalen Gwatay [Show all 10 contributors for this article] (2019). Immunomodulatory activities of polysaccharides isolated from plants used as antimalarial in Mali. Journal of Pharmacognosy and Phytotherapy. ISSN 2141-2502. 11(2), p. 35–42. doi: 10.5897/JPP2019.0547.
• Bräunlich, Paula Marie; Inngjerdingen, Kari Tvete; Inngjerdingen, Marit; Johnson, Quinton; Paulsen, Berit Smestad & Mabusela, Wilfred (2018). Polysaccharides from the South African medicinal plant Artemisia afra: Structure and activity studies. Fitoterapia. ISSN 0367-326X. 124, p. 182–187. doi: 10.1016/j.fitote.2017.11.016. Full text in Research Archive
• Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E. & Duus, Jens Øllgaard [Show all 7 contributors for this article] (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga). Carbohydrate Polymers. ISSN 0144-8617. 185, p. 27–40. doi: 10.1016/j.carbpol.2017.12.041. Full text in Research Archive
• Zou, Yuan-Feng; Fu, Yu-Ping; Chen, Xing-Fu; Austarheim, Ingvild; Inngjerdingen, Kari Tvete & Huang, Chao [Show all 13 contributors for this article] (2017). Polysaccharides with immunomodulating activity from roots of Gentiana crassicaulis. Carbohydrate Polymers. ISSN 0144-8617. 172, p. 306–314. doi: 10.1016/j.carbpol.2017.04.049.
• Zou, Yuanfeng; Fu, Yu-Ping; Chen, Xing-Fu; Austarheim, Ingvild; Inngjerdingen, Kari Tvete & Huang, Chao [Show all 14 contributors for this article] (2017). Purification and partial structural characterization of a complement fixating polysaccharide from rhizomes of Ligusticum chuanxiong. Molecules. ISSN 1431-5157. 22(2), p. 1–11. doi: 10.3390/molecules22020287.
• Zou, Yuanfeng; Barsett, Hilde; Ho, Giang Thanh Thi; Inngjerdingen, Kari Tvete; Diallo, Drissa & Michaelsen, Terje Einar [Show all 7 contributors for this article] (2015). Immunomodulating pectins from root bark, stem bark, and leaves of the Malian medicinal tree Terminalia macroptera, structure activity relations. Carbohydrate Research. ISSN 0008-6215. 403, p. 167–173. doi: 10.1016/j.carres.2014.05.004.
• Zou, Yuanfeng; Zhang, Bingzhao; Inngjerdingen, Kari Tvete; Barsett, Hilde; Diallo, Drissa & Michaelsen, Terje Einar [Show all 7 contributors for this article] (2014). Complement activity of polysaccharides from three different plant parts of Terminalia macroptera extracted as healers do. Journal of Ethnopharmacology. ISSN 0378-8741. 155(1), p. 672–678. doi: 10.1016/j.jep.2014.06.017.
• Zhang, Bingzhao; Inngjerdingen, Kari Tvete; Zou, Yuanfeng; Rise, Frode; Michaelsen, Terje Einar & Yan, Pei-Sheng [Show all 7 contributors for this article] (2014). Characterisation and immunomodulating activities of exo-polysaccharides from submerged cultivation of Hypsizigus marmoreus. Food Chemistry. ISSN 0308-8146. 163, p. 120–128. doi: 10.1016/j.foodchem.2014.04.092.
• Zou, Yuanfeng; Ho, Giang Thanh Thi; Malterud, Karl Egil; Le, Nhat Hao Tran; Inngjerdingen, Kari Tvete & Barsett, Hilde [Show all 9 contributors for this article] (2014). Enzyme inhibition, antioxidant and immunomodulatory activities, and brine shrimp toxicity of extracts from the root bark, stem bark and leaves of Terminalia macroptera. Journal of Ethnopharmacology. ISSN 0378-8741. 155(2), p. 1219–1226. doi: 10.1016/j.jep.2014.07.004.
• Zou, Yuanfeng; Chen, Xing-Fu; Malterud, Karl Egil; Rise, Frode; Barsett, Hilde & Inngjerdingen, Kari Tvete [Show all 8 contributors for this article] (2014). Structural features and complement fixing activity of polysaccharides from Codonopsis pilosula Nannf. var. modesta L.T.Shen roots. Carbohydrate Polymers. ISSN 0144-8617. 113, p. 420–429. doi: 10.1016/j.carbpol.2014.07.036.
• Zou, Yuanfeng; Zhang, Bingzhao; Barsett, Hilde; Inngjerdingen, Kari Tvete; Diallo, Drissa & Michaelsen, Terje Einar [Show all 7 contributors for this article] (2014). Complement Fixing Polysaccharides from Terminalia macroptera Root Bark, Stem Bark and Leaves. Molecules. ISSN 1431-5157. 19(6), p. 7440–7458. doi: 10.3390/molecules19067440.
• Inngjerdingen, Kari Tvete; Thöle, Christian; Diallo, Drissa; Paulsen, Berit Smestad & Hensel, Andreas (2014). Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by aqueous extracts and pectic polysaccharides from the roots of Cochlospermum tinctorium A. Rich. and Vernonia kotschyana Sch. Bip. ex Walp. Fitoterapia. ISSN 0367-326X. 95, p. 127–132. doi: 10.1016/j.fitote.2014.03.009.
• Zou, Yuanfeng; Zhang, Bingzhao; Inngjerdingen, Kari Tvete; Barsett, Hilde; Diallo, Drissa & Michaelsen, Terje Einar [Show all 8 contributors for this article] (2014). Polysaccharides with immunomodulating properties from the bark of Parkia biglobosa. Carbohydrate Polymers. ISSN 0144-8617. 101(1), p. 457–463. doi: 10.1016/j.carbpol.2013.09.082.
• Inngjerdingen, Kari Tvete; Ballo, Ngolo; Zhang, Bingzhao; Malterud, Karl Egil; Michaelsen, Terje Einar & Diallo, Drissa [Show all 7 contributors for this article] (2013). A comparison of bioactive aqueous extracts and polysaccharide factions from roots of wild and cultivated Cochlospermum tinctorium A. Rich. Phytochemistry. ISSN 0031-9422. 93, p. 136–143. doi: 10.1016/j.phytochem.2013.03.012.
• Inngjerdingen, Kari Tvete; Langerud, Beathe Kiland; Rasmussen, Henrik; Olsen, Trude Karin; Austarheim, Ingvild & Grønhaug, Tom Erik [Show all 10 contributors for this article] (2013). Pectic polysaccharides isolated from Malian medicinal plants protect against Streptococcus pneumoniae in a mouse pneumococcal infection model. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(5), p. 372–388. doi: 10.1111/sji.12047.
• Austarheim, Ingvild; Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad; Togola, Adiaratou; Diakite, Chiaka & Diallo, Drissa (2013). Chromatographic immunoassays for Helicobacter pylori detection - are they reliable in Mali, West Africa? Pan African Medical Journal. ISSN 1937-8688. 14. doi: 10.11604/pamj.2013.14.72.2131.
• Odontuya, G; Enkhmaa, G; Naran, Radnaa; Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar & Paulsen, Berit Smestad (2012). Pharmacological Activities of a Moingolian Medicinal Plant, Malva mohielviensis Down. European Journal of Medicinal Plants. ISSN 2231-0894. 2(3), p. 230–241.
• Austarheim, Ingvild; Mahamane, Haidara; Sanogo, Rokia; Togola, Adiaratou; Khaledabadi, Mehdi & Vestrheim, Anne Cathrine [Show all 10 contributors for this article] (2012). Anti-ulcer polysaccharides from Cola cordifolia bark and leaves. Journal of Ethnopharmacology. ISSN 0378-8741. 143(1), p. 221–227. doi: 10.1016/j.jep.2012.06.027. Show summary

  ABSTRACT Ethnopharmacological relevance: Aqueous extracts of bark and leaves of C. cordifolia are traditionally used in Mali (West Africa) in the treatment of wounds and gastric ailments like abdominal pain, gastritis and gastric ulcers. Aim of the study: To evaluate and compare the anti-ulcer and immunological activities, as well as the toxicity of polysaccharide rich water extracts from the bark and leaves of C. cordifolia. Materials and Methods: Gastric ulcers were induced in rats and the inhibition of ulcer formation was calculated based on lesion index. Immunological activities were measured by complement fixation and macrophage activation. Toxicity was tested on brine shrimps. The two extracts were characterized by GC, Yariv-precipitation and quantification of phenolic compounds. An ethnomedical survey on C. cordifolia was carried out in Siby (Mali, West-Africa) to generate more knowledge about the traditional use. Results: Bark and leaf extracts from C. cordifolia significantly inhibited the formation of gastric lesions in rodents in a dose depending manner. CCbark50 showed a high complement fixation activity in vitro. No toxicity was found. The ethnomedical survey showed that C. cordifolia was mainly used for treating pain and wounds. Conclusions: Our results shows that the bark and the leaves comprise a dose dependent anti-ulcer activity in an experimental rat model (no statistical difference between the plant parts). Clinical studies should be performed to evaluate the effect of both bark and leaves of C. cordifolia as a remedy against gastric ulcer in human.

• Inngjerdingen, Kari Tvete; Meskini, Selma; Austarheim, Ingvild; Ballo, Ngolo; Inngjerdingen, Marit & Michaelsen, Terje Einar [Show all 8 contributors for this article] (2012). Chemical and biological characterization of polysaccharides from wild and cultivated roots of Vernonia kotschyana. Journal of Ethnopharmacology. ISSN 0378-8741. 139(2), p. 350–358. doi: 10.1016/j.jep.2011.10.044.
• Koschella, Andreas; Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad; Morris, Gordon A.; Harding, Stephen & Heinze, Thomas (2008). Unconventional methyl galactan synthesized via the thexyldimethylsilyl intermediate: Preparation, characterization, and properties. Macromolecular Bioscience. ISSN 1616-5187. 8.
• Nyamdari, Batbayar; Banzragch, Dana; Inngjerdingen, Kari Tvete; Naran, Radnaa; Michaelsen, Terje Einar & Paulsen, Berit Smestad (2008). Polysaccharides from Mongolian plants and their effect on the complement system:1. Polysaccharides from plants of the Asteraceae family. Asian Journal of Traditional Medicine. ISSN 1817-4337. 3(1), p. 33–41.
• Inngjerdingen, Marit; Inngjerdingen, Kari T; Patel, Trushar R; Allen, Stephanie; Chen, Xinyong & Rolstad, Bent [Show all 11 contributors for this article] (2008). Pectic polysaccharides from Biophytum petersianum Klotzsch, and their activation of macrophages and dendritic cells. Glycobiology. ISSN 0959-6658. 18(12), p. 1074–1084. doi: 10.1093/glycob/cwn090.
• Batbayar, N; Banzragch, Dana; Inngjerdingen, KT; Naran, Radnaa; Michaelsen, Terje Einar & Paulsen, BS (2008). Polysaccharides from Mongolian plants and their effect on the complement system: 1.Polysaccharides from plants of Asteraceae family. Asian Journal of Traditional Medicine. ISSN 1817-4337. 3, p. 33–41.
• Ballance, Simon; Borsheim, Knut Yngve; Børsheim, Knut Yngve; Inngjerdingen, Kari Tvete; Ingjerdingen, Kari & Paulsen, Berit Smestad [Show all 7 contributors for this article] (2007). A re-examination and partial characterisation of polysaccharides released by mild acid hydrolysis from the chlorite-treated leaves of Sphagnum papillosum. Carbohydrate Polymers. ISSN 0144-8617. 67, p. 104–115. doi: 10.1016/j.carbpol.2006.04.020.
• Inngjerdingen, Kari T.; Kiyohara, Hiroaki; Matsumoto, Tsukasa; Petersen, Dirk; Michaelsen, Terje Einar & Diallo, Drissa [Show all 9 contributors for this article] (2007). An immunomodulating pectic polymer from Glinus oppositifolius. Phytochemistry. ISSN 0031-9422. 68(7), p. 1046–1058. doi: 10.1016/j.phytochem.2007.01.011.
• Inngjerdingen, Kari T.; Patel, Trushar; Chen, X; Xinyong, Chen; Kenne, Lennart & Allen, Stephanie [Show all 14 contributors for this article] (2007). Immunological and structural properties of a pectic polymer from Glinus oppositifolius. Glycobiology. ISSN 0959-6658. 17(12), p. 1299–1310. doi: 10.1093/glycob/cwm088.
• Inngjerdingen, K.T.; Coulibaly, A.; Diallo, D.; Michaelsen, Terje Einar & Paulsen, B.S. (2006). A complement fixing polysaccharide from Biophytum petersianum Klotzsch, a medicinal plant from Mali, West Africa. Biomacromolecules. ISSN 1525-7797. 7(1), p. 48–53. doi: 10.1021/bm05030h. Show summary

  Biophytum petersianum Klotzsch (syn. Biophytum sensitivum (L.) DC) is a medicinal plant having a traditional use, among others, as a wound healing remedy in Mali and other countries. As a water extract of the aerial parts of the plant is a frequently used preparation, we decided to look for a bioactive polysaccharide in this extract. One of the obtained polysaccharide fractions, BP100 III, isolated from a 100 degrees C water extract from the aerial parts of B. petersianum and having a monosaccharide composition typical for pectic substances, was shown to exhibit potent dose-dependent complement fixating activity. The BP100 III fraction was subjected to degradation by endo-alpha-d-(1-->4)-polygalacturonase, and three fractions were obtained by gel filtration. The highest molecular weight fraction, BP100 III.1, had a more potent activity in the complement test system than the native polymer, while the two lower molecular weight fractions were less active than the native polymer. The major part of BP100 III.1 consists of galacturonic acid and rhamnose, with branches being present on both the rhamnose and galacturonic acid residues. Arabinogalactan type II is also present in the polymer, indicating that BP100 III.1 has a structure typical of the hairy region of pectins. The major part of the two other fractions is a galacturonan, containing a strikingly high number of branch points, some to which xylose is attached. These results indicate that the pectic substance in B. petersianum contains both rhamnogalacturonan and xylogalacturonan regions.

• Nergård, Cecilie Sogn; Matsumoto, Tsukasa; Inngjerdingen, Marit; Inngjerdingen, Kari Tvete; Hokputsa, Sanya & Harding, Stephen E. [Show all 11 contributors for this article] (2005). Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydrate Research. ISSN 0008-6215. 340, p. 115–130.
• Nergård, Cecilie Sogn; Diallo, Drissa; Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar; Matsumoto, Tsukasa & Kiyohara, Hiroaki [Show all 8 contributors for this article] (2005). Medicinal use of Cochlospermum tinctorium in Mali. Anti-ulcer, radical scavenging and immunomodulating activities of polymers in the aqueous extracts of the roots. Journal of Ethnopharmacology. ISSN 0378-8741. 96, p. 255–269.
• Inngjerdingen, Kari Tvete; Debes, Sylvi C; Inngjerdingen, Marit; Hokputsa, Sanya; Harding, Stephen E. & Rolstad, Bent [Show all 9 contributors for this article] (2005). Bioactive pectic polysaccharides from Glinus oppositifolius (L). Aug. DC., a Malian medicinal plant, isolation and partial characterization. Journal of Ethnopharmacology. ISSN 0378-8741. 101, p. 204–214.
• Nergard, CS; Diallo, D; Inngjerdingen, Kt; Michaelsen, Terje Einar; Matsumoto, T & Kiyohara, H [Show all 8 contributors for this article] (2005). Medicinal use of Cochlospermum tinctorium in Mali Anti-ulcer-, radical scavenging- and immunomodulating activities of polymers in the aqueous extract of the roots. Journal of Ethnopharmacology. ISSN 0378-8741. 96, p. 255–269. Show summary

  Cochlospermum tinctorium A. Rich. (Cochlospermaceae) is a widely used medicinal plant in the West African country, Mali. An ethnopharmacological survey was conducted and 106 traditional practitioners interviewed. The roots were the part of the plant reported to be the most frequently used for medicinal purposes. The main indications were to treat jaundice (41), gastro intestinal diseases or ailments (28), malaria (12), schistosomiasis (10) and dysurea (6). A high-molecular weight water extract (25, 50 and 100 mg/kg, body weight) significantly inhibited HCl/ethanol-induced gastric lesions in mice. The extract showed DPPH-radical scavenging- and immunomodulating activities in vitro. The main components of the extract were identified as polysaccharides (59.3%) and polyphenols (9.3%). The polysaccharides were purified and characterised as highly complex pectic arabinogalactans type II. As parts of the polyphenol compounds gallotannins and ferulic acids were identified. This study shows that the polysaccharides are partly responsible for the bioactivities observed in vitro. Both polysaccharides and polyphenols may be responsible for the anti-ulcer activities observed.

• Nergard, CS; Matsumoto, T; Inngjerdingen, M; Inngjerdingen, KT; Hokputsa, S & Harding, S [Show all 11 contributors for this article] (2005). Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydrate Research. ISSN 0008-6215. 340, p. 115–130. Show summary

  Two polysaccharides, a pectin (Vk100A2b) and a pectic arabinogalactan (Vk100A2a) with mean Mw 2 x 10(4) and 1.15 x 10(6)Da, respectively, were isolated from the dried powdered roots of Vernonia kotschyana Sch. Bip. ex Walp. by hot water extraction followed by fractionation on DEAE-Sepharose fast flow and Sephacryl S-400 HR. The pectin showed low-complement fixation activity and no influence on proliferation of B or T cells, while the pectic arabinogalactan showed a potent, dose-dependent complement fixation activity and a T cell independent induction of B-cell proliferation. Both polysaccharides induced chemotaxis of human macrophages, T cells and NK cells. exo-alpha-L-arabinofuranosidase and exo-beta-D-galactosidase digestion followed by component sugar and methylation analysis indicated that Vk100A2a consisted of a highly branched rhamnogalacturonan core with approximately 50% of the rhamnose 1,2,4-substituted, side chains rich in terminal-, 1,5-linked and 1,3,5-branched arabinose and terminal-, 1,4-, 1,6-linked and 1,3,6-branched galactose. The enzyme resistant part of Vk100A2a still showed strong complement fixating activity, suggesting that this activity may at least in part be expressed by carbohydrate structures present in the enzyme resistant, inner portion of the polymer.

• Inngjerdingen, KT; Debes, SC; Inngjerdingen, M; Hokputsa, S; Harding, S & Rolstad, B [Show all 9 contributors for this article] (2005). Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization. Journal of Ethnopharmacology. ISSN 0378-8741. 101, p. 204–214. doi: 10.1016/j.jep.2005.04.021. Show summary

  Glinus oppositifolius (L.) Aug. DC. (Aizoaceae) is a Malian medicinal plant used against various types of illnesses related to the immune response, like joint pains, inflammations, fever, malaria and wounds. Two pectin type polysaccharides, GOA1 and GOA2, being isolated from a 50 degrees C water extract from the aerial parts of Glinus oppositifolius were investigated for their activity towards the complement system and different leukocyte subsets because of the assumed effects on conditions related to the immune system. The polysaccharide polymer in GOA1 was shown to contain considerable amounts of the neutral sugars arabinose (26.4 mol%) and galactose (42.9 mol%), and methylation analysis indicated the presence of arabinogalactans type I (AG-I) and type II (AG-II). GOA2 was rich in galacturonic acid (68.3 mol%), along with rhamnose, arabinose and galactose. Structural studies indicated that rhamnose and galacturonic acid might constitute a rhamnogalacturonan backbone, often found in pectic substances, with side chains consisting of arabinose and galactose. Both GOA1 and GOA2 were shown to exhibit potent dose-dependent complement fixating activities, and induced chemotaxis of macrophages, T cells and NK cells.

• Hokputsa, Sanya; Gerddit, Waraporn; Pongsamart, Sunanta; Inngjerdingen, Kari Tvete; Heinze, Thomas & Koschella, Andreas [Show all 8 contributors for this article] (2004). Water-soluble polysaccharides with pharmaceutical importance from Durian rinds (Durio zibethinus Murr.): Isolation, fractionation, characterisation and bioactivity. Carbohydrate Polymers. ISSN 0144-8617. 56(4), p. 471–481.
• Hokputsa, Sanya; Harding, Stephen; Inngjerdingen, Kari Tvete; Jurnel, Kornelia; Michaelsen, Terje Einar & Heinze, Thomas [Show all 8 contributors for this article] (2004). Bioactive polysaccharides from the stems of the Thai medicinal plant Acanthus ebracteatus: their chemical and physical features. Carbohydrate Research. ISSN 0008-6215. 339(4), p. 753–762.
• Inngjerdingen, Kari Tvete; Nergård, Cecilie Sogn; Diallo, D; Mounkoro, PP & Paulsen, Berit Smestad (2004). An ethnopharmacological survey of plants used for wound healing in Dogonland, Mali, West Africa. Journal of Ethnopharmacology. ISSN 0378-8741. 92(2-3), p. 233–244.
• Hokputsa, S; Harding, S; Inngjerdingen, KT; Jumel, K; Michaelsen, Terje Einar & Heinze, T [Show all 8 contributors for this article] (2004). Bioactive polysaccharides from the stems of the Thai medicinal plant Acanthus ebracteatus: their chemical and physical features. Carbohydrate Research. ISSN 0008-6215. 339, p. 753–762. Show summary

  Crude water-soluble polysaccharides were isolated from Acanthus ebracteatus by hot water extraction followed by ethanol precipitation after pre-treatment with 80% ethanol. The crude polysaccharides were separated into neutral and acidic polysaccharides by anion-exchange chromatography. The neutral polysaccharide (A1001) was rich in galactose, 3-O-methylgalactose and arabinose, whereas the acidic polysaccharide (A1002) consisted mainly of galacturonic acid along with rhamnose, arabinose and galactose as minor components indicating a pectin-type polysaccharide with rhamnogalacturonan type I (RG-1) backbone. 3-O-Methylgalactose is also present in the acidic fraction. Both neutral and acidic fractions showed potent effects on the complement system using pectic polysaccharide PM II from Plantago major as a positive control. A small amount of 3-O-methylgalactose present in the pectin seemed to be of importance for activity enhancement in addition to the amount of neutral sugar side chains attached to RG-1. The relationship between chemical structure and effect on the complement system of the isolated polysaccharides is considered in the light of these data. The presence of the rare monosaccharide 3-O-methylgalactose may indicate that this can be used as a chemotaxonomic marker. The traditional way of using this plant as a medical remedy appears to have a scientific basis

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• Harding, Stephen E; Tombs, Michael; Adams, Gary G.; Paulsen, Berit Smestad; Inngjerdingen, Kari Tvete & Barsett, Hilde (2017). An Introduction to Polysaccharide Biotechnology. CRC Press. ISBN 9781482246971. 225 p.

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• Hoel, Håvard & Inngjerdingen, Kari Tvete (2023). Naturmedisiner fra glemmeboken.
• Ulriksen, Emilie Steinbakk; Esam, Nabila; Butt, Hussain Shakeel; Wangensteen, Helle; Hamre, Anne Grethe & Inngjerdingen, Marit [Show all 7 contributors for this article] (2023). Chemical and immunological profiling of polysaccharides from roots of Angelica archangelica L.
• Butt, Hussain Shakeel; Ulriksen, Emilie Steinbakk; Inngjerdingen, Marit; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2023). Structural characterisation of phenolic compounds from the bark of Daphne mezereum L.
• Bada, Lucia; Wangensteen, Helle; Inngjerdingen, Kari Tvete; Gil-Longo, Jose; Quezada, Elias & Vina, Dolores (2023). Antitumoral potential of sub-fractions obtained from Ulex gallii Planch. in human neuroblastoma (SH-SY5Y) and glioblastoma (U-87MG and U-373MG) cell lines.
• Ohrvik, Ane; Inngjerdingen, Kari Tvete; Inngjerdingen, Marit & Kool, Anneleen (2023). Middelaldermedisinen er tilbake. [Radio]. NRK P2. Show summary

  I jakten på nye behandlingsmetoder går forskerne til legebøker fra middelalderen, og henter gamle medisinplanter inn i laboratoriet. Kan disse brukes til å utvikle nye medisiner?

• Ohrvik, Ane; Inngjerdingen, Marit; Inngjerdingen, Kari Tvete & Kool, Anneleen (2023). Svartebøker og gammel folketro inspirerer moderne medisin. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926. p. 50–57.
• Zhang, Lin; Sandvik, Lene; Hoel, Håvard; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2022). Phytochemical screening of Gentiana purpurea, an important Norwegian medicinal plant.
• Fu, Yu-Ping; Zou, Yuan-Feng; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2022). Phenolics and polysaccharides isolated from the roots of Aconitum septentrionale, a Norwegian medicinal plant.
• Inngjerdingen, Kari Tvete (2022). Immunomodulatory effects of polysaccharides isolated from old Norwegian medicinal plants.
• Zhang, Lin; Sandvik, Lene; Ulriksen, Emilie Steinbakk; Hoel, Håvard; Malterud, Karl Egil & Inngjerdingen, Kari Tvete [Show all 8 contributors for this article] (2022). Søterot, en bitter og glemt norsk medisinplante.
• Moussavi, Nastaran; Azizullah, Hasina; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2022). Immunomodulating polyphenols from Sideritis scardica.
• Blakeney, Rebecca Angelica; Rydmark, Marcella Christine Orwick; Ulriksen, Emilie Steinbakk; Heien, Greta Karoline; Butt, Hussain Shakeel & Kool, Anneleen [Show all 8 contributors for this article] (2021). Exhibition: Pharmaceutical Time Travels: From Ancient Plant Remedies to Modern Medicines / Utstilling: Farmasøytisk tidsreise: Fra historiske planteremedier til moderne medisiner.
• Moussavi, Nastaran; Azizullah, Hasina; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2021). Greek mountain tea, Sideritis scardica, a medicinal plant from the Mediterranean and Balkans with antioxidant and anti-inflammatory activities.
• Inngjerdingen, Kari Tvete; Inngjerdingen, Marit; Wangensteen, Helle; Butt, Hussain Shakeel; Ulriksen, Emilie & Rasmussen Steien, Tore (2020). Graver i skogen og arkiver på leting etter nygamle legemidler. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935.
• Wold, Christian Winther; Corthay, Alexandre; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2020). Myteomspunnen kjuke frå folkemedisin til mogleg kreftbehandling. www.forskning.no.
• Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from Mediterranean countries and Balkan.
• Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from the Mediterranean countries and Balkan.
• Zou, Yuanfeng; Barsett, Hilde; Ho, Giang Thanh Thi; Inngjerdingen, Kari Tvete; Diallo, Drissa & Michaelsen, Terje Einar [Show all 7 contributors for this article] (2015). A complement fixing polysaccharide from root bark of Terminalia macroptera.
• Inngjerdingen, Kari Tvete (2013). Blant medisinmenn i Mali.
• Paulsen, Berit Smestad; Diallo, Drissa; Nergård, Cecilie Sogn; Inngjerdingen, Kari Tvete; Inngjerdingen, Marit & Togola, Adiaratou [Show all 8 contributors for this article] (2011). Woundhealing plants as tarets for identification of pectins with immunomodulating effects.
• Langerud, Beathe Kiland; Inngjerdingen, Kari Tvete; Rasmussen, Henrik; Olsen, Trude Karin; Austarheim, Ingvild & Aaberge, Ingeborg Sundsvalen [Show all 9 contributors for this article] (2011). Pectic Polysaccharides Isolated from Malian Medicinal Plants can Prevent Bacteraemia and Clinical Symptoms in a Mouse Pneumococcal Infection Model. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 390–390.
• Inngjerdingen, Kari Tvete; Diallo, Drissa & Paulsen, Berit Smestad (2010). Kan kultiverte planter erstatte viltvoksende medisinplanter?
• Inngjerdingen, Kari Tvete; Nergård, Cecilie Sogn; Inngjerdingen, Marit; Diallo, Drissa; Michaelsen, Terje Einar & Paulsen, Berit Smestad (2010). Structure/activity relations of immunomodulating pectic polysaccharides from Malian medicinal plants.
• Inngjerdingen, Kari Tvete; Inngjerdingen, Marit; Patel, Trushar; Allen, Stephanie; Chen, Xinyong & Morris, Gordon A. [Show all 10 contributors for this article] (2009). Pectic polymers from Biophytum petersianum Klotsch - avtivation of macrophages and dendritic cells.
• Inngjerdingen, M; Togola, Adiaratou; Grønhaug, Tom Erik; Inngjerdingen, KT; Nergard, CS & Evjenth, Ragnhild Kårvatn [Show all 9 contributors for this article] (2008). A comparison of immunomodulating activity of pectic polysaccharides isolated from Malian medisinal plants.
• Inngjerdingen, Marit; Togola, Adiaratou; Grønhaug, Tom Erik; Inngjerdingen, Kari Tvete; Nergaard, Cecilie Sogn & Evjenth, Ragnhild Kårvatn [Show all 9 contributors for this article] (2008). A comparison of immunomodulating activity of pectic polysacchraides isolated from Malian mediisinal plants.
• Ballance, Simon; Børsheim, k; Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad & Christensen, Bjørn Erik (2008). Partial charaterisation of polysaccharides released by mild acid hydrolysis from the chlorite-treated leaves of Sphagnum papillosum.
• Inngjerdingen, Marit; Inngjerdingen, Kari Tvete; Sveaas, Anne; Diallo, Drissa; Michaelsen, Terje Einar & Paulsen, Berit Smestad (2007). Immunomodulating activity of a polysccharide isolated from Biophytum petersianum, a medicinal plant from Mali.
• Inngjerdingen, Marit; Togola, Adiaratou; Grønhaug, Tom Erik; Inngjerdingen, Kari Tvete; Evjenth, Ragnhild Kårvatn & Austarheim, Ingvild Marie [Show all 10 contributors for this article] (2007). A comparison of immunomodulating activity of pectic polysaccharides isolated from three Malian medicinal plants.
• Koschella, Andreas; Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad; Morris, G.A.; Harding, Stephen E. & Heinze, Thomas (2007). Methyl Galactan Synthesdized via the Thexyldimethylsilyl Intermediate: Preparation, Characterisation and Properties.
• Inngjerdingen, Kari Tvete; Diallo, Drissa; Michaelsen, Terje Einar & Paulsen, Berit Smestad (2006). Structure/activity Relations of Immunomodulating Pectic Polysaccharides from the Malian medicinal plant Glinus oppositifolius (L.) Aug. DC.
• Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad; Diallo, Drissa & Michaelsen, Terje Einar (2005). Structure/activity relations of a complemnet fixing pectic polysaccharide from the Malian medicinal Plant Biophytum petersianum Klotzch.
• Paulsen, Berit Smestad; Nergård, Cecilie Sogn; Inngjerdingen, Kari Tvete & Diallo, Drissa (2005). Structural aspects of bioactive pectic polysaccharides from Malian medicinal plants.
• Paulsen, Berit Smestad; Nergård, Cecilie Sogn; Diallo, Drissa & Inngjerdingen, Kari Tvete (2005). Bioactive polysaccharides from the Malian medicinal plants Cochlospermum tinctorium.
• Inngjerdingen, Kari Tvete; Engdal, Silje; Michaelsen, Terje Einar; Diallo, Drissa & Paulsen, Berit Smestad (2005). Isolation and partial characterisation of biological active pectic polysaccharides from Combretum glutinosum Perr. ex DC.
• Inngjerdingen, Kari Tvete; Paulsen, Berit Smestad; Diallo, Drissa & Michaelsen, Terje Einar (2005). Structure/Activity relations of a complement fixing pectic polysaccharide from the Malian medicinal plant Biophytum petersianum Klotzsch.
• Inngjerdingen, Kari Tvete; Engdal, Silje; Michaelsen, Terje Einar; Diallo, Drissa & Paulsen, Berit Smestad (2005). Isolation and partial characterization of biological active pectic polysaccharides from Combretum glutinosum Perr. ex DC.
• Paulsen, Berit Smestad; Diallo, Drissa; Inngjerdingen, Kari Tvete & Michaelsen, Terje Einar (2004). Structure/activity relations of a complement fixing pectic polysaccharide from the Malian medicinal plant Biophytum petersianum.
• Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar; Paulsen, Berit Smestad & Diallo, Drissa (2003). Sårhelende planter fra Mali; Feltarbeid i Dogonland og studier over medisinplanten Glinus oppositifolius (L.) A. DC.
• Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar; Paulsen, Berit Smestad & Diallo, Drissa (2003). A pectic arabinogalactan with complement fixing ability from Glinus oppositifolius (L.) A. DC. - a plant used for woundhealing in Mali.
• Batbayar, N.; Banzragch, D; Paulsen, Berit Smestad & Inngjerdingen, Kari Tvete (2003). Polysaccharides from Plants grown in Mongolia IV.
• Batbayar, N.; Banzragch, D; Paulsen, Berit Smestad; Inngjerdingen, Kari Tvete; Oyun, H & Yamiansan, Ya [Show all 8 contributors for this article] (2003). Polysaccharides from plants grown in Mongolia. III.
• Batbayar, N.; Banzragch, D; Paulsen, Berit Smestad & Inngjerdingen, Kari Tvete (2003). Polysaccharides from Plants grown in Mongolia, II. Root Polysaccharides.
• Batbayar, N.; Banzragch, D; Paulsen, Berit Smestad & Inngjerdingen, Kari Tvete (2003). Polysaccharides from Plants grown in Mongolia. 1. Asteraceae plants.
• Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar; Diallo, Drissa & Paulsen, Berit Smestad (2003). Isolation and prtial characterisation of a biological active pectic arabinogalactan from Glinus oppositifolius (L.) A.DC.
• Inngjerdingen, Kari Tvete; Michaelsen, Terje Einar; Diallo, Drissa & Paulsen, Berit Smestad (2003). A biological active pectic arabinogalactan from Glinus oppositifolius (L.) A.DC.
• Hokputsa, Sanya; Harding, Stephen E.; Inngjerdingen, Kari Tvete & Paulsen, Berit Smestad (2003). Bioactive polysaccharides from Acanthus ebracteatus.

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