Jannicke and Trond Vidar have published an interesting article together with collaborators at Duke University and Harvard Medical School. In this article, the authors show that specialized pro-resolving mediators, such as protectin D1 and PD1n-3 DPA, as well as a novel synthetic analog, all potently reduce pain and itch in mice. The new synthetic analog 3-oxa-PD1n-3 DPA is of interest as a lead towards developing new immunoresolvents and new CNS-active drugs.
The article is found here: https://pubs.rsc.org/en/content/articlepdf/2021/ob/d0ob02136a
Congratulations to Jannicke and Trond Vidar!