We congratulate dr. Elisabeth Opsjøn Lampe with her PhD entitled "The fish pathogen Francisella noatunensis subsp noatunensis: viruelence factor characterization and vaccine development". Thanks to the evaluation committee consisting of Prof Marina Santic, senior scientist Jean-Pierre Levraud and Liv Mathiesen for the evaluation of the thesis and interesting discussion of Elisabeth's work.
A new collaborative publication out on the function of extracellular vesicles secreted from the porcine pathogenic bacterium Actinobacillus pleuropneumoniae. The work was mainly performed by the PhD student Zhuang Zhu in the laboratory of Miki Bojesen at the Veterinary School, University of Copenhagen.
Ellen Beate Tysvær (left) is doing her BSc in biosciences at Department of Biosciences, UiO. She received a fellowship from UiO:Life Sciences to work as a summer student in the MicroPath group. She is working on a project isolating extracellular vesicles from E. coli expressing outer membrane proteins from the fish bacterial pathogen Yersinia ruckeri and testing them as a vaccine against the disease yersiniosis in aquaculture. Ellen-Beate is supervised by our PhD student Verena Mertes (right) in the laboratory.
Gabriela Paz Carril Leiva is an associated PhD student of the MicroPath group. Gabriela is form Chile and is doing her PhD at NMBU on interaction of the fish pathogen P. salmonis with its host, the Atlantic salmon. Gabriela has prof Henning Sørum as her main supervisor, and Prof Hanne C. Winther-Larsen and Marie Løvoll (VESO) as co-supervisors on this project. This spring Gabriela defended her 3rd semester evaluation at NMBU.
PhD student Verena Mertes was part of the organizing body of the The National Graduate School in Infection Biology and Antimicrobials (IBA) annual meeting 2022. She also presented her scientific work at the poster session.
PhD student Verena Mertes could after two years of the Covid-19 pandemic finally participate at the Fish Immunology workshop in Wageningen, The Netherlands.
PhD student Verena Mertes participates and present her work at the poster session at the International Society of Extracellular Vesicles (ISEV) annual meeting 2022 in Lyon, France.
MSc Rebekka Rolfsnes, an employee of the Norwegian start-up biotech company Adjutec Pharma, started her PhD with us the first of April 2022. We are glad to have Rebekka back in the group after she did her MSc thesis with us in 2020 on bacterial fish vaccines. Rebekka will do her PhD on the project entitled: The novel antimicrobial resistance breaker APC247 – studies on mechanism of action (MoA) and resistance development to a putative dual SBL/MBL inhibitor. The project is funded by the Norwegian Research Council.
Lucia is an ERASMUS+ exchange student from the university in Valencia. She will work together with our PhD candidate Verena Mertes on a project to create green and red fluorescent versions of the fish pathogenic bacterium Yersinia ruckeri. Lucia is staying with us from March to the summer of 2022.
MicroPath contribute with transmission electron microcopy and immuno fluorescence microcopy in a publication in mBio, describing regulated expression of Type IV pili in the pathogenic bacterium Pseudomonas aerugionsa
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787478/
From the research exchange visit from Dr. Javiera Ortiz in 2018, Javiera set up an Alamar blue in vitro based assay for measuring infections by the fish bacterial pathogen P. salmonis in salmon and zebrafish cells. The MicroPath research group contributed to this work and the publication in MDPI Microorganisms.
The MicroPath group is attending the EMBO work-shop on Bacterial Membrane Vesicles, hosted by Tsukuba University, Japan. Our research was presented on a poster describing the thorough genomic, transcriptomic and proteomic analysis of vesicles from Vibrio cholerae performed by a previous PhD student in the lab Petter Langlete and our collaborator Anders Krabberød.
MicroPath is hosting a work-shop to coordinate a joint research collaboration on antimicrobial resistance. Attending was Ole Andreas Økstad, Katrine Lekang (University of Oslo), Hege Salvesen Blix (Norwegian Institute of Public Health), Henning Sørum (NMBU) and Samuel Raj (SRM University, India). The work-shop was funded by the Research Council of Norway.
Verena Mertes attended the annual meeting of IBA: The National Graduate School in Infection Biology and Antimicrobials 1st - 2nd November 2021. She presented a poster on her PhD thesis work on bacterial membrane vesicles, their role in virulence and possible function as a vaccine in aquaculture.
With the help of Fabio Antenucci, Klaus Qvortup and Michael Johnson we performed cryoEM imaging of bacterial extracellular vesicles from the fish pathogen Yersinia ruckeri. The vesicles were isolated by Verena Mertes from the Y. ruckeri ompA mutant. The cryoEM was performed at CFIM - Core facility for Intergrated Microscopy at University of Copenhagen.
Nora Haukeland spent her UiO Life:Science summer internship at the MicroPath research group. As part of the program Nora presented her work at a poster session 19th October at UiO. Her poster was entitled: Membrane Vesicle Vaccine For The Fish Pathogen Yersinia ruckeri.
It was a pleasure having Nora in our lab!
Post-doctoral research fellow Maxim Bril`kov from Department of Pharmacy, University of Tromsø is on a research visit at the MicroPath group. He is together with our PhD student Verena Mertes, exploring the use of the tangential flow filtration technology for isolating bulk amounts of bacterial extracellular vesicles. The research visit is funded by Nordic POP https://nordicpop.com
MicroPath attending a common seminar with Miki Bojesens research group at the University of Copenhagen on the topic of antimicrobial resistance, vaccine development and microbiom research in a One Health setting.
Hanne Winther-Larsen spend part of her research sabbatical at the group of Miki Bojesen at Department of Veterinary and Animal Sciences, University of Copenhagen. She is together with Dr. Fabio Antenucci characterizing membrane vesicles secreted from the fish pathogen Yersinia ruckeri.
Hybrid hydrogels for bacteriocin delivery to infected wounds by Thapa, Winther-Larsen, Ovchinnikov, Carlsen, Diep and Tønnesen.
We are happy to contribute to in a collaborative publication with the research groups of Prof Diep (NMBU) and Prof Tønnesen (Department of Pharmacy, University of Oslo, on the use of the antimicrobial peptides against wound infections. Congratulations to all co-authors.
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