Colon drug delivery is though quite difficult to obtain. The formulation must withstand the harsh environment as well as the variable transit time in the stomach. In addiiton the shift in pH when going from the stomach to the small intestine is also challenging. Numerous approaches have been tried to obtain colon drug delivery such as a pH dependant approach and a time dependant approach. In addition, a promising approach is to rely on bipolymers that will be degraded enzymatically when entering the colon.
The group has been working with the topic of intestinal drug delivery as well as colon drug delivery for several years.