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Trial lecture - time and place
31.03.2023, 10.15. Auditorium 2, Helga Eng
Drug shortages in intensive care - How can knowledge in pharmaceutics contribute to patient safety?
Conferral summary
Denne avhandlingen har undersøkt hvilke intravenøse legemidler som kan og ikke kan administreres sammen i den intravenøse kateterslangen og innovative metoder for å detektere uforlikelighet.
Main research findings
Paediatric intensive care patients are in need of numerous intravenous (i.v.) drugs. Due to the shortage of i.v. catheters, two or more drugs have to be given in the same i.v. line, i.e. co-administered. A major challenge is the risk of precipitation, the formation of solid particles, which may occur when the drugs do not tolerate each other. Because of this, the i.v. catheter can become blocked, the patient may get the solid particles lodged in body organs, small capillaries might be blocked and destabilisation of the drug can occur.
This Thesis has contributed with knowledge of which drugs in multi-drug regimens are safe and not safe to co-administer intravenously. Parenteral nutrition containing lipids was found to be safe to be co-administered with specific antibiotics, drugs that affect the blood pressure and pain relieving drugs. Commonly used intravenous fluids (buffered electrolytes) were shown to be unsafe to co-administer with certain drugs used for sedation. This Thesis used both well-established methods and explored innovative methods for detecting and identifying particles formed due to incompatibility of combined drugs.
Read more
- Tryggare medisinering av for tidleg fødde (Titan, 20. mai 2022)
- Seksåring fekk legemiddel intravenøst – pumpa gjekk tett (Titan, 22. feb. 2023)