Trial lecture - time and place
15.12.2023, 10.15, Auditorium 1, Helga Eng
BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in connection with lipophilicity and hydrophilicity
Conferral summary
Det er et økende behov for nye, bærekraftige og prediktive in vitro metoder til bruk i farmasøytisk forskning og utvikling. Dette prosjektet har lagt grunnmuren for videreutviklingen av slike verktøy innen permeabilitetstesting, ved å kombinere eksperimentelle observasjoner og matematiske modeller.
Main research findings
The complex and costly process of drug development has traditionally relied on empirical methods and involved extensive, time-consuming trials in vivo, i.e., on living organisms. However, with our society’s heightened awareness of resource scarcity and ethics, conventional approaches have been deemed inadequate and the demand for sustainable and predictive laboratory, i.e., in vitro, methods has emerged.
This paradigm shift is crucial but progress hinges on a deeper understanding of the studied phenomena. For assays evaluating drugs’ ability to transverse biological membranes in in vitro models, the presence of an unstirred water layer (UWL) adjacent to the barrier significantly impacts the rate and extent of the process.
This thesis delved into this layer's composition and its influence on drug permeability through an artificial PermeaPad® membrane in two distinct systems – a high-throughput screening plate and a novel organ-on-chip device allowing UWL manipulation. Data from drug diffusion through UWLs was combined with mathematical models in order to parametrise drug loading and release kinetics into/from nanosized enabling formulations. The results unveil UWL's varied impact on different compounds, showcasing the role of various intrinsic factors. This thesis established the foundation of future research into the development of enhanced in vitro tools for drug development.
Read more (in Norwegian)
- Matematiske modellar skal erstatta dyreforsøk (forskning.no, 10. feb. 2023)
- Nanopartiklar kan få deg til å ta medisin som smaker vondt (forskning.no, 27.1.2021)