Trial lecture - time and place
23.05.2024, 10.15, Auditorium 2, Helga Eng
The use of physiology-based pharmacokinetic modeling to predict drug-drug interactions
Conferral summary
En av de største utfordringene innen moderne legemiddelbehandling er den store variasjonen i legemiddelrespons både innad og mellom individer. I dette doktorgradsarbeidet er det utviklet avanserte farmakokinetiske modeller for å beskrive og forutsi hvordan legemidler omsettes i kroppen. Ved å benytte disse modellene kan behandling og diagnostikk av legemidler forbedres for pasientgrupper med sykelig overvekt, cerebrospinalvæskeforstyrrelser og redusert nyrefunksjon.
Main research findings
This dissertation investigates the variability in drug response among individuals and presents methods to personalize drug dosing to improve therapeutic outcomes. Variability in drug effectiveness and safety represents a significant challenge in modern medicine. By employing "probe drugs," such as rosuvastatin, gadobutrol, and iohexol, the research provides insights into how drugs are processed in the body. The findings show that factors like obesity or weight loss procedures, such as strict diet and gastric bypass, do not influence how rosuvastatin is cleared from the body. This suggests that dosage adjustments might not be necessary in these circumstances. Another study using gadobutrol reveals significant differences in how fluid is cleared from the brain across various neurological disorders, contributing to better understanding and diagnosis of brain fluid dynamics. Additionally, iohexol clearance is used to precisely measure kidney function, leading to improved methods for monitoring renal health. Overall, these studies emphasize the importance of pharmacometrics—using mathematical models to predict drug behavior—to tailor drug dosing. This approach enhances the effectiveness and safety of drug treatments, contributing to more personalized healthcare solutions.
Read more (in Norwegian):
- Med tungrekning vert det enklare å gje persontilpassa medisinering (Titan, 29. juli 2020)
- Min hjerne og din hjerne skil ut legemiddel ulikt (Titan, 29. aug. 2022)
- Opnar for meir slingringsmonn når nyrefunksjon skal testast (FAI, 3. mai 2023)
- Nyretransplanterte pasienter kan oppnå god beskyttelse mot COVID-19 ved vaksinasjon (OUS' fagblogg, juni 2023)
- Ubetydeleg endring i opptak av legemiddel etter kraftig vekttap (Titan, 7. aug. 2023)