The research activities of Dr. Dalli focus on a new area in biomedicine named resolution of inflammation.
Excessive acute inflammation and chronic unresolved inflammation have been linked to the development of several human diseases. The resolution phase of inflammation is regulated by endogenously enzymatically produced compounds named specialized pro-resolving mediators (SPMs).
Dr. Dalli has contributed significantly to the fundamental understanding on how SPMs participate in the resolution of inflammation. He has published more than 80 scientific articles that include contributions in Nature Medicine, Journal of Experimental Medicine, Cell Biology and Proceedings of the National Academy of Sciences of the United States of America.
In his lecture Dr. Dalli will provide a background to the biochemical and biological processes behind the resolution of inflammation, discuss the potent in vivo bioactions that SPMs exhibit in several human disease models and the different biochemical pathways forming SPMs. His research has been highlighted by the New England Journal of Medicine and he is a holder of several international patents.
Selected references:
Dalli, J, et. al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc Natl Acad Sci U S A 2016, 113(43), 12232-7.
Dalli J, et al. Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015 (9):1071-5.
Chiang N, Dalli J, Colas RA, Serhan CN. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. J Exp Med. 2015 212(8):1203-17.
Dalli J.et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proc Natl Acad Sci U S A. 2014 111(46):16526-31.
Dalli J, Chiang N, Serhan CN. Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proc Natl Acad Sci U S A; 111(44):E4753-61.
Mirakaj V, Dalli J, et al. Vagus nerve controls resolution and pro-resolving mediators of inflammation. J Exp Med. 2014;211(6):1037-48