Disputas: Tung Si Ho

Prøveforelesning

Bedømmelseskomité

Lars Blomberg, Institutionen för kemi, Karlstad universitet, Sverige
Einar Jensen, Institutt for Farmasi, Universitetet i Tromsø
Berit Smedstad Paulsen, Farmasøytisk institutt, Universitetet i Oslo

Sammendrag

The work was carried out at the Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo.

The trend in sample preparation science is moving towards miniaturization. This is because miniaturized techniques have several advantages compared to conventional sample preparation techniques such as liquid-liquid extraction and solid-phase extraction. These advantages include speed, low consuming of harmful organic solvent, simplicity, low cost, high enrichment and ease of automation. Liquid-phase microextraction (LPME) is a miniaturized form of liquid – liquid extraction and is based on immobilization of organic solvents in the pores of porous hollow fibers. This technique was developed in our laboratory and was introduced in 1999. In LPME, analytes are extracted from an aqueous sample, through a thin film of immobilized organic solvent and into an acceptor phase inside the lumen of the fiber.

At the start of this project little fundamental information about LPME was available and in addition no applications on the microextraction of hydrophilic drugs from biological solutions were reported. This thesis has generated fundamental information about LPME which is crucial for the further development of the technique and for the technique to be generally accepted. In addition this study has successfully further developed a new extraction technique for polar drugs from plasma and urine.

Kontaktperson

For mer informasjon, kontakt Karen Marie Ulshagen.