Prøveforelesning
Se prøveforelesningBedømmelseskomité
Associate professor Andrew Marston, Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, Sveits
Associate professor Birgit Classen, Pharmaceutical Institute, Department of Pharmaceutical Biology, University of Kiel, Tyskland
Førsteamanuensis Trond Vidar Hansen, Farmasøytisk institutt, Avdeling for farmasøytisk kjemi, Universitetet i Oslo
Leder av disputas: Karen Marie Ulshagen
Veileder: Berit Smestad Paulsen
Sammendrag
*The context of the study: In Mali, a majority of the population use plants extracts (infusion or decoction like tea, or the dry powder of the leaves, roots, stem bark, flowers seeds) to cure diseases. This practice is name “Traditional Medicine” and those detaining the knowledge of what plant cure to use for what disease are called "Traditional Healers".
*The research subject: In this Thesis we evaluated the healing potential of three medicinal plants, Opilia celtidifolia, Cola cordifolia and Erythrina senegalensis that are claimed by traditional healers to be effective in the treatment of wounds (skin and organ injuries) and bacterial infections, and then used by the Malian population.
*The results: The plants that was claimed to have internal (gastric ulcer) and external wound healing activity showed a potent activity on the human immune system (using human blood tested in laboratory experiments). This activity is a good indication that these plants truly have the wound healing activity as claimed by traditional healers. The group of compounds present in the plant extracts that are responsible for the wound healing activity are called "Polysaccharides". The plant used by traditional healers against bacterial infection also killed bacteria that have been cultivated in the laboratory and the group of compounds responsible for the antibacterial activity is named "Flavonoids". They also showed anti-oxidant or radical scavenging activities.
*The conclusion: All the results were positive showing that traditional healers in Mali have the right knowledge about diseases and the plants that should be used to treat them. In Mali at DMT it is planned to make plant medicines called "phytomedicines" or ITMs (Improved Traditional Medicines) from these plants that will be sold in pharmacies as a complement to conventional medicine.
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