The PhD defence and trial lecture will be streamed. The chair of the defence will moderate the disputation.
Ex auditorio questions: the chair of the defence will invite the audience physically present in the auditorium to ask ex auditorio questions.
→ Live streaming of trial lecture and disputation
→ Request for thesis copy (available until the disputation starts)
Trial lecture
Time and place: May 31, 2024; 9:15 AM, - Lille Fysiske auditorium (V232) - Fysikkbygningen
Title: “TGF-B3: do biological consequences, efficacy and mechanism of action depend on LET?”
Main research findings
Ionizing radiation is an important tool in modern medicine. However, radiation may damage healthy tissues and cause side effects which can negatively impact patients’ quality of life. Therefore, methods to modulate the radiosensitivity of biological tissues are of interest.
Transforming growth factor-beta 3 (TGF-β3) is a protein that is expressed by all tissues and involved in various normal and pathological functions. TGF-β3 is known to increase the resistance of cultured cells to low doses of radiation.
In her thesis, Ingunn Hanson has investigated the ability of TGF-β3 to modulate biological radiosensitivity and identified the receptor bound by TGF-β3 to mediate this effect, as well as the secretion and activation methods of TGF-β3.
Contrary to other studies, TGF-β3 increased acute and long-term radiation injuries in a mouse model of normal tissue toxicity in head and neck cancer radiotherapy. However, in a mouse model of whole-body exposure to high-dose radiation, TGF-β3 treatment did not affect the progression or lethality of acute radiation syndrome. Shielding of a portion of bone marrow during irradiation decreased gastrointestinal radiotoxicity and increased survival.
The results presented in this thesis highlight the complex nature of the modulation of radiosensitivity by TGF-β3 and provide a foundation for further research on the topic.
Adjudication Committee
- Dr. Ludwig Dubois, Maastricht University, the Netherlands
- Professor Siamak Haghdoost, Université de Caen Normandie/Stockholms universitet, Sweeden
- Dr. Caroline Stokke, University of Oslo, Norway
Supervisors
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Associate Professor Nina F. J. Edin, Department of Physics, University of Oslo, Norway
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Professor Eirik Malinen, Department of Physics, University of Oslo, Norway
Chair of defence
Associate professor Helge Balk, Department of Physics, University of Oslo, Norway
Candidate contact information
E-mail: ingunn.hanson@fys.uio.no
Contact information to Department: Line Trosterud Resvold