Ivar Thokle Hovden

• Fuster-Garcia, Elies; Hovden, Ivar Thokle; Svensson, Siri Fløgstad; Larsson, Christopher; Vardal, Jonas & Bjørnerud, Atle [Vis alle 7 forfattere av denne artikkelen] (2022). Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival. Cancers. ISSN 2072-6694. 14(7). doi: 10.3390/cancers14071725.
• Svensson, Siri Fløgstad; Fuster i Garcia, Elies; Latysheva, Anna; Fraser-Green, Jorunn; Nordhøy, Wibeke & Darwish, Omar Isam [Vis alle 11 forfattere av denne artikkelen] (2021). Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow. European Journal of Radiology. ISSN 0720-048X. 147. doi: 10.1016/j.ejrad.2021.110136. Fulltekst i vitenarkiv
• Hovden, Ivar Thokle; Geier, Oliver; Digernes, Ingrid; Fuster i Garcia, Elies; Løvland, Grethe & Vik-Mo, Einar O. [Vis alle 8 forfattere av denne artikkelen] (2020). The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma. European Journal of Radiology. ISSN 0720-048X. doi: 10.1016/j.ejrad.2020.109278. Vis sammendrag

  Purpose Relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC)-MRI is a valuable biomarker in patients with glioblastoma for assessing treatment response and predicting overall survival. DSC-MRI based on echo planar images (EPI) may possess severe geometric distortions from magnetic field inhomogeneities up to the order of centimeters. The aim of this study is to assess how much two readily available EPI-based geometric distortion correction methods, FSL TOPUP and EPIC, affect rCBV values from DSC-MRI in patients with confirmed glioblastoma. Method We used a combined single-shot 2D gradient-echo (T2*), spin-echo (T2) EPI sequence to estimate both T2* and T2-weighted rCBV from the same contrast agent injection. Effects of distortion correction on the positive phase-encoded T2- and T2*-images were assessed in healthy anatomical brain regions in terms of Wilcoxon signed rank tests on median rCBV change and on Dice coefficients, as well as in tumor lesions in terms of Wilcoxon signed rank tests on median rCBV change. Results Our results show that following distortion correction, both gradient-echo and spin-echo rCBV increased in cortical areas of the frontal, temporal and occipital lobe, including the posterior orbital gyri in the frontal lobe and middle frontal gyri (p 

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