Frode Miltzow Skjeldal

The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T.
Immunity. 2010 Oct 29;33(4):583-96. Epub 2010 Oct 7.

PMID:

    20933442
    [PubMed - indexed for MEDLINE]

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2.
Toll-like receptor 2 (P631H) mutant impairs membrane internalization and is a dominant negative allele.
Etokebe GE, Skjeldal F, Nilsen N, Rodionov D, Knezevic J, Bulat-Kardum L, Espevik T, Bakke O, Dembic Z.
Scand J Immunol. 2010 May;71(5):369-81.

PMID:

    20500688
    [PubMed - indexed for MEDLINE]

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3.
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36.
Nilsen NJ, Deininger S, Nonstad U, Skjeldal F, Husebye H, Rodionov D, von Aulock S, Hartung T, Lien E, Bakke O, Espevik T.
J Leukoc Biol. 2008 Jul;84(1):280-91. Epub 2008 May 5.

PMID:

    18458151
    [PubMed - indexed for MEDLINE]

Free Article
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4.
Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator.
Steffensen KR, Bouzga M, Skjeldal F, Kasi C, Karahasan A, Matre V, Bakke O, Guérin S, Eskild W.
BMC Mol Biol. 2007 Nov 16;8:106.

PMID:

    18021396
    [PubMed - indexed for MEDLINE]

Free PMC Article
Free full text

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• Skjeldal, Frode Miltzow; Haugen, Linda Hofstad; Nunes De C Mateus, Duarte; Frei, Dominik Michael; Rødseth, Anna Vik & Hu, Xian [Show all 7 contributors for this article] (2021). De novo formation of early endosomes during Rab5-to-Rab7a transition. Journal of Cell Science. ISSN 0021-9533. 134(8). doi: 10.1242/jcs.254185. Full text in Research Archive Show summary

  Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal maturation switch, where Rab5 is gradually exchanged by Rab7a on the same endosome. Here, we provide new insight into the mechanism of endosomal maturation, for which we have discovered a stepwise Rab5 detachment, sequentially regulated by Rab7a. The initial detachment of Rab5 is Rab7a independent and demonstrates a diffusion-like first-phase exchange between the cytosol and the endosomal membrane, and a second phase, in which Rab5 converges into specific domains that detach as a Rab5 indigenous endosome. Consequently, we show that early endosomal maturation regulated through the Rab5-to-Rab7a switch induces the formation of new fully functional Rab5-positive early endosomes. Progression through stepwise early endosomal maturation regulates the direction of transport and, concomitantly, the homeostasis of early endosomes.

• Kocere, Agnese; Resseguier, Julien; Wohlmann, Jens; Skjeldal, Frode Miltzow; Khan, Shanawaz & Speth, Martin [Show all 14 contributors for this article] (2020). Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis. EBioMedicine. ISSN 2352-3964. 58, p. 1–12. doi: 10.1016/j.ebiom.2020.102902. Full text in Research Archive
• Mousavi, Seyed Ali; Skjeldal, Frode Miltzow; Fønhus, Marita Sporstøl; Haugen, Linda Hofstad; Eskild, Winnie & Berg, Trond [Show all 7 contributors for this article] (2019). Receptor-mediated endocytosis of VEGF-A in rat liver sinusoidal endothelial cells. BioMed Research International. ISSN 2314-6133. 2019, p. 1–12. doi: 10.1155/2019/5496197. Full text in Research Archive
• Fauskanger, Marte; Haabeth, Ole Audun; Skjeldal, Frode Miltzow; Bogen, Bjarne & Tveita, Anders (2018). Tumor killing by CD4+ T cells is mediated via induction of inducible nitric oxide synthase-dependent macrophage cytotoxicity. Frontiers in Immunology. ISSN 1664-3224. 9:1684, p. 1–13. doi: 10.3389/fimmu.2018.01684. Full text in Research Archive
• Fenaroli, Federico; Repnik, Urska; Xu, Yitian; Johann, Kerstin; Van Herck, Simon & Dey, Pradip [Show all 15 contributors for this article] (2018). Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models. ACS Nano. ISSN 1936-0851. 12(8), p. 8646–8661. doi: 10.1021/acsnano.8b04433.
• Haugen, Linda Hofstad; Skjeldal, Frode Miltzow; Bergeland, Trygve & Bakke, Oddmund (2017). Endosomal binding kinetics of Eps15 and Hrs specifically regulate the degradation of RTKs. Scientific Reports. ISSN 2045-2322. 7:17962, p. 1–13. doi: 10.1038/s41598-017-17320-2. Full text in Research Archive
• Kucera, Ana; Distefano, Marita Borg; Berg-Larsen, Axel; Skjeldal, Frode Miltzow; Repnik, Urska & Bakke, Oddmund [Show all 7 contributors for this article] (2016). Spatiotemporal Resolution of Rab9 and CI-MPR Dynamics in the Endocytic Pathway. Traffic: The moving front of cell biology. ISSN 1398-9219. 17(3), p. 211–229. doi: 10.1111/tra.12357.
• Hansson, Kenth-Arne; Døving, Kjell Bjarne & Skjeldal, Frode Miltzow (2015). Mixed input to olfactory glomeruli from two subsets of ciliated sensory neurons does not impede relay neuron specificity in the crucian carp. Journal of Experimental Biology. ISSN 0022-0949. 218(20), p. 3257–3263. doi: 10.1242/jeb.125476.
• Berven, Lise; Skjeldal, Frode Miltzow; Prydz, Kristian; Zubaidi, Layla Mohammad Khader; Ballance, Simon & Johansen, Harald Thidemann [Show all 7 contributors for this article] (2015). Particulate yeast β-glucan is internalized by RAW 264.7 macrophages and reduces the activity of the tumor-associated protease legumain. Bioactive Carbohydrates and Dietary Fibre. ISSN 2212-6198. 6(1), p. 15–23. doi: 10.1016/j.bcdf.2015.06.003.
• Bagheri Fam, Shahla; Skjeldal, Frode Miltzow; Griffiths, Gareth Wyn; Mælandsmo, Gunhild; Engebråten, Olav & Nyström, Bo [Show all 8 contributors for this article] (2015). pH-Responsive Nano Carriers for Doxorubicin Delivery. Pharmaceutical Research. ISSN 0724-8741. 32(4), p. 1249–1263. doi: 10.1007/s11095-014-1530-0.
• Fenaroli, Federico; Westmoreland, David; Benjaminsen, Jørgen; Kolstad, Terje R Selnes; Skjeldal, Frode Miltzow & Meijer, Annemarie H. [Show all 12 contributors for this article] (2014). Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment. ACS Nano. ISSN 1936-0851. 8(7), p. 7014–7026. doi: 10.1021/nn5019126.
• Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger & Bakke, Oddmund [Show all 8 contributors for this article] (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology. ISSN 0014-2980. 43(10), p. 2577–2587. doi: 10.1002/eji.201243203.
• Skjeldal, Frode Miltzow; Strunze, Sten; Bergeland, Trygve; Walseng, Even; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). The fusion of early endosomes induces molecular-motor-driven tubule formation and fission. Journal of Cell Science. ISSN 0021-9533. 125(8), p. 1910–1919. doi: 10.1242/jcs.092569.
• Husebye, Harald; Aune, Marie Hjelmseth; Stenvik, Jørgen; Samstad, Eivind Ottersen; Skjeldal, Frode Miltzow & Halaas, Øyvind [Show all 13 contributors for this article] (2010). The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity. ISSN 1074-7613. 33(4), p. 583–596. doi: 10.1016/j.immuni.2010.09.010.
• Etokebe, GE; Skjeldal, F; Nilsen, Nadra; Rodionov, Dmitrii; Knezevic, Jelena & Bulat-Kardum, Ljiljana [Show all 9 contributors for this article] (2010). Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(5), p. 369–381. doi: 10.1111/j.1365-3083.2010.02379.x. Full text in Research Archive
• Nilsen, Nadra; Deininger, S; Nonstad, Unni; Skjeldal, F; Husebye, Harald & Rodionov, D [Show all 12 contributors for this article] (2008). Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. Journal of Leukocyte Biology. ISSN 0741-5400. 84, p. 280–291. doi: 10.1189/jlb.0907656.
• Steffensen, Knut Rune; Bouzga, Mariam; Skjeldal, Frode; Kåsi, Cecilie; Karahasan, Almira & Matre, Vilborg [Show all 9 contributors for this article] (2007). Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. BMC Molecular Biology. ISSN 1471-2199. 8(1), p. 106–120.

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• Samuelsen, Anne Berit C.; Berven, Lise; Rabani, Helai; Zubaidi, Layla & Skjeldal, Frode Miltzow (2015). Immunomodulating activities of fungal beta-glucans seem superior to those of cereal beta-glucans in vitro.
• Sundvold-Gjerstad, Vibeke; Kristiansen, Tone Fredsvik; Granum, Stine; Berge, Tone; Koster, Gerbrand & Skjeldal, Frode Miltzow [Show all 9 contributors for this article] (2011). T cell Specific Adapter Protein (TSAd) Relocates the Tec Family Protein Tyrosine Kinase Itk from the Plasma Membrane to the Perinuclear Area. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 359–359.
• Doving, KB; Skjeldal, Frode Miltzow; Sandvig, Kirsten; Bakke, Oddmund; Heikkinen, I & Larsen, HK [Show all 7 contributors for this article] (2009). Fish Chemosenses; Olfaction, Taste, and Ligand-Specific Endocytosis. Chemical Senses. ISSN 0379-864X. 34(3), p. E13–E13.

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