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Pressebilde

Faglige interesser

Bacterial adhesion mechanisms

The lack of knowledge about bacterial adhesion mechanisms hinders the development of novel antibacterial surfaces. Consequences are failing implants, inefficient electrodes, and biofouling of off-shore materials. The current, slow approach to this problem is trial-and-error testing of potentially beneficial surface modifications. We are pursuing a bottom-up approach, starting with molecular biology studies of bacterial adhesion factors, and of their interaction with surfaces.

My project involves the development of bacteria-surface adhesion assays, to obtain new knowledge on adhesin function. Secondly, I will translate the results into novel surface modifications to test the theories, leading to more effective antibacterial surfaces, and the improvement of the adhesion assays. These aims will be achieved in close collaboration with the Department of Biomaterials (BIOMAT) at the University of Oslo Institute for Clinical Dentistry.

Bakgrunn

PhD in Chemistry at the University of Bath

Purpose: Development of electrode materials for photo-microbial fuel cells.

Essential discovery: Inherently conductive Ti₂AlC ceramic enabled the fabrication of reticulated electrode shapes with defined porosity and good surface roughness for improved cell adhesion, thereby maximising the area for electricity generating cells.

Kontaktinformasjon

Kontortelefon: +47 228 54793

Kontor på IBV i rommet: 3523

Laboratorium på IBV i rommet: 3522

Finansiering historie

2017-2019: Marie Sklodowska-Curie Individual Fellowship Grant agreement No: 704903; Action acronym: BAC-STAR; Full action title: Bacterial Adhesion Control through Surface TArgeted Regulation BAC-STAR
2015-2017: University of Oslo
2015: Oslo University Hospital
2010-2014: Engineering and Physical Sciences Research Council EPSRC ref.: EP/H046305/1; Grant title: Nano-Integration of Metal-Organic Frameworks and Catalysis for the Uptake and Utilisation of CO₂
2009-2010: Erasmus Programme (European Region Action Scheme for the Mobility of University Students)

Mer informasjon

Linkedin: https://uk.linkedin.com/in/kenneth-schneider-b5633070

Google Scholar Profile: https://scholar.google.com/citations?user=aTUvAFoAAAAJ&hl=de

Emneord: Materials science, Surface chemistry, adhesion

“An investigation of anode and cathode materials in photomicrobial fuel cells” in Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences, 2016. 374: p.2061. (Kenneth Schneider, Rebecca J Thorne, Petra J Cameron)

“Iron reduction by the cyanobacterium Synechocystis sp. PCC 6803” in Bioelectrochemistry, 2015. 105: p. 103-109. (Rebecca Thorne, Kenneth Schneider, Huaining Hu and Petra J. Cameron)

“A small-scale air-cathode microbial fuel cell for on-line monitoring of water quality” in Biosensors and Bioelectronics, 2014. 62(0): p. 182-188. (Mirella Di Lorenzo, Alexander R. Thomson, Kenneth Schneider, Petra J. Cameron, Ioannis Ieropoulos).

“Trapping of redox-mediators at the surface of Chlorella vulgaris leads to error in measurements of cell reducing power” in Physical Chemistry Chemical Physics, 2014. 16(12): p. 5810-5816. (Rebecca J. Thorne, Huaining Hu, Kenneth Schneider and Petra J. Cameron).

“Surface morphology and surface energy of anode materials influence power outputs in a multi-channel mediatorless bio-photovoltaic (BPV) system” in Physical Chemistry Chemical Physics, 2012. 14(35): p. 12221-12229. (Paolo Bombelli, Marie Zarrouati, Rebecca J. Thorne, Kenneth Schneider, Stephen J. L. Rowden, Akin Ali, Kamran Yunus, Petra J. Cameron, Adrian C. Fisher, D. Ian Wilson, Christopher J. Howe and Alistair J. McCormick).

“Porous ceramic anode materials for photo-microbial fuel cells” in Journal of Materials Chemistry, 2011. 21(44): p. 18055-18060. (Rebecca Thorne, Huaining Hu, Kenneth Schneider, Paolo Bombelli, Adrian Fisher, Laurence M. Peter, Andrew Dent and Petra J. Cameron).

Moldovan, Rebeca; Milenko, Karolina Barbara; Vereshchagina, Elizaveta; Iacob, Bogdan-Cezar; Schneider, Kenneth & Farcău, Cosmin [Vis alle 7 forfattere av denne artikkelen] (2022). EC-SERS detection of thiabendazole in apple juice using activated screen-printed electrodes. Food Chemistry. ISSN 0308-8146. 405. doi: 10.1016/j.foodchem.2022.134713. Fulltekst i vitenarkiv Vis sammendrag
Thiabendazole (TBZ), a benzimidazole fungicide used for post-harvest treatment, may be a trace contaminant of food matrices. In this work, we report the first EC-SERS (electrochemical-surface enhanced Raman spectroscopy) detection of TBZ in spiked apple juice using electrochemically (EC) roughened, gold-based screen-printed electrodes (AuSPEs) and portable instrumentation. Polarizing the substrate (−0.8 V vs Ag/AgCl) improves the recorded SERS signal of TBZ, allowing to reach a limit of detection (LOD) in juice of 0.061 ppm with a relatively wide linear range (0.5–10 μM) and good intermediate precision (%RSD
Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Pérez-Ortega, Jesús; Sittman, Carolin; Göttig, Stephan & Liskiewicz, Krystyna Anna [Vis alle 11 forfattere av denne artikkelen] (2020). The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence. Environmental Microbiology. ISSN 1462-2912. 22(7), s. 2939–2955. doi: 10.1111/1462-2920.15051. Fulltekst i vitenarkiv
Chauhan, Nandini; Hatlem, Daniel; Rydmark, Marcella Orwick; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Vis alle 8 forfattere av denne artikkelen] (2019). Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA). Molecular Microbiology. ISSN 0950-382X. 111(3), s. 844–862. doi: 10.1111/mmi.14195. Fulltekst i vitenarkiv
Schneider, Kenneth; Thorne, Rebecca Jayne & Cameron, Petra J. (2016). An investigation of anode and cathode materials in photomicrobial fuel cells. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. ISSN 1364-503X. 374(2061). doi: 10.1098/rsta.2015.0080.

Se alle arbeider i Cristin

Moldovan, Rebeca; Milenko, Karolina Barbara; Vereshchagina, Elizaveta; Iacob, Bogdan-Cezar; Schneider, Kenneth & Farcău, Cosmin [Vis alle 7 forfattere av denne artikkelen] (2022). EC-SERS Spectroelectrochemical Detection of Thiabendazole Residues in Juice. Vis sammendrag
The discovery of surface enhanced Raman scattering (SERS) from an electrochemical (EC)-SERS experiment is known as a historic breakthrough. Since then, great progress has been made in using this technique for various analytical purposes, Raman spectroelectrochemistry representing now a promising alternative to conventional analytical methods. By manipulating the surface charge through polarization, the physico-chemical interaction between the substrate and the target molecule can be controlled and facilitated. As a result, a higher enhancement of the Raman signal is observed. The EC modulation of substrate potentials during SERS analysis brings a series of other benefits, such as higher selectivity, possibility of preconcentration, reusability and improved reproducibility. Furthermore, the electrochemical methods for "roughening" (activation) of the low-cost screen-printed electrodes offer a convenient, accessible, and ready-to-use alternative to commercially available SERS substrates that are expensive and sometimes irreproducible. In this work we report the first EC-SERS detection of thiabendazole, a systemic fungicide used in agriculture that can be found as a contaminant in various foods, including fruit juices. The EC-SERS measurements were performed using a portable Raman spectrometer and a potentiostat. Commercially available gold screen-printed electrodes were used after an optimized electrochemical activation procedure. An applied potential to the substrate (-0.8V vs. Ag/AgCl) further increases the SERS signal of thiabendazole allowing its detection down to 0.06 ppm (0.3 μM), with a relatively wide linear range (0.5 - 10 μM) and good intermediate precision (RSD%
Hatlem, Daniel; Chauhan, Nandini; Orwick-Rydmark, Marcella; Schneider, Kenneth; Flötenmeyer, Matthias & Van Rossum, Barth-J [Vis alle 8 forfattere av denne artikkelen] (2019). Insights into the autotransport of a trimeric autotransporter.
Chauhan, Nandini; Hatlem, Daniel; Orwick-Rydmark, Marcella; Schneider, Kenneth; Linke, Dirk & Leo, Jack Christopher (2019). Using the SpyCatcher-SpyTag technology for topology mapping of outer membrane proteins in Gram-negative bacteria.
Hatlem, Daniel; Chauhan, Nandini; Rydmark, Marcella Orwick; Schneider, Kenneth; Floetenmeyer, Matthias & Leo, Jack Christopher [Vis alle 7 forfattere av denne artikkelen] (2018). Insights into the autotransporter process of a trimeric autotransporter, Yersinia Adhesin A (YadA).
Schneider, Kenneth; Haugen, Håvard Jostein & Linke, Dirk (2017). Assay Development: Adhesin Interaction with Implant Materials.
Schneider, Kenneth; Saragliadis, Athanasios; Haugen, Håvard Jostein & Linke, Dirk (2016). Aggregatibacter Adhesins and their interaction with implant materials.
Leo, Jack Christopher; Schneider, Kenneth & Linke, Dirk (2015). Autotransporters as mediators of bacterial adhesion.