Kjetill Sigurd Jakobsen

• Konstantinidis, Ioannis; Sætrom, Pål; Brieuc, Marine Servane Ono; Jakobsen, Kjetill Sigurd; Liedtke, Hannes & Pohlmann, Caroline [Vis alle 8 forfattere av denne artikkelen] (2023). DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden. Epigenetics. ISSN 1559-2294. 18(1). doi: 10.1080/15592294.2023.2282323. Fulltekst i vitenarkiv Vis sammendrag

  Phenotypic plasticity of metabolism and growth are essential for adaptation to new environmental conditions, such as those experienced during domestication. Epigenetic regulation plays a key role in this process but the underlying mechanisms are poorly understood, especially in the case of hydroxymethylation. Using reduced representation 5-hydroxymethylcytosine profiling, we compared the liver hydroxymethylomes in full-sib Nile tilapia with distinct growth rates (3.8-fold difference) and demonstrated that DNA hydroxymethylation is strongly associated with phenotypic divergence of somatic growth during the early stages of domestication. The 2677 differentially hydroxymethylated cytosines between fast- and slow-growing fish were enriched within gene bodies (79%), indicating a pertinent role in transcriptional regulation. Moreover, they were found in genes involved in biological processes related to skeletal system and muscle structure development, and there was a positive association between somatic growth and 5hmC levels in genes coding for growth factors, kinases and receptors linked to myogenesis. Single nucleotide polymorphism analysis revealed no genetic differentiation between fast- and slow-growing fish. In addition to unveiling a new link between DNA hydroxymethylation and epigenetic regulation of growth in fish during the initial stages of domestication, this study indicates that epimarkers may be applied in selective breeding programmes for superior phenotypes.

• Reinar, William Brynildsen; Tørresen, Ole K.; Nederbragt, Lex; Matschiner, Michael; Jentoft, Sissel & Jakobsen, Kjetill Sigurd (2023). Teleost genomic repeat landscapes in light of diversification rates and ecology. Mobile DNA. ISSN 1759-8753. 14(1), s. 1–12. doi: 10.1186/s13100-023-00302-9. Fulltekst i vitenarkiv
• Kersten, Oliver Sven; Star, Bastiaan; Krabberød, Anders Kristian; Atmore, Lane; Tørresen, Ole K. & Anker-Nilssen, Tycho [Vis alle 12 forfattere av denne artikkelen] (2023). Hybridization of Atlantic puffins in the Arctic coincides with 20th-century climate change. Science Advances. ISSN 2375-2548. 9(40). doi: 10.1126/sciadv.adh1407. Fulltekst i vitenarkiv Vis sammendrag

  The Arctic is experiencing the fastest rates of global warming,leading to shifts in the distribution of its biota and increasing the potential for hybridization. However, genomic evidenc eof recent hybridization events in the Arctic remains unexpectedly rare. Here, we use whole-genome sequencing of contemporary and 122-year-old historical specimens to investigate the origin of an Arctic hybrid population of Atlantic puffins(Fratercula arctica) on Bjørnøya, Norway. We show that the hybridization between the High Arctic, large-bodied subspecies F.a. naumanni and the temperate, smaller-sized subspecies F.a. arctica began as recently as six generations ago due to an unexpected southward range expansion of F.a. naumanni. Moreover, we find a significant temporal loss of genetic diversity across Arctic and temperate puffin populations.Our observations provide compelling genomic evidence of the impacts of recent distributional shifts and loss of diversity in Arctic communities during the 20th century.

• Dussex, Nicolas; Tørresen, Ole Kristian; van der Valk, Tom; Le Moullec, Mathilde; Veiberg, Vebjørn & Tooming-Klunderud, Ave [Vis alle 17 forfattere av denne artikkelen] (2023). Adaptation to the High-Arctic island environment despite long-term reduced genetic variation in Svalbard reindeer. iScience. ISSN 2589-0042. 26(10). doi: 10.1016/j.isci.2023.107811. Fulltekst i vitenarkiv Vis sammendrag

  Typically much smaller in number than their mainland counterparts, island populations are ideal systems to investigate genetic threats to small populations. The Svalbard reindeer (Rangifer tarandus platyrhynchus) is an endemic subspecies that colonized the Svalbard archipelago ca. 6,000–8,000 years ago and now shows numerous physiological and morphological adaptations to its arctic habitat. Here, we report a de-novo chromosome-level assembly for Svalbard reindeer and analyze 133 reindeer genomes spanning Svalbard and most of the species’ Holarctic range, to examine the genomic consequences of long-term isolation and small population size in this insular subspecies. Empirical data, demographic reconstructions, and forward simulations show that long-term isolation and high inbreeding levels may have facilitated the reduction of highly deleterious—and to a lesser extent, moderately deleterious—variation. Our study indicates that long-term reduced genetic diversity did not preclude local adaptation to the High Arctic, suggesting that even severely bottlenecked populations can retain evolutionary potential.

• Reinar, William Brynildsen; Greulich, Anne; Stø, Ida Myhrer; Knutsen, Jonfinn Mordekai Blix; Reitan, Trond & Tørresen, Ole K. [Vis alle 9 forfattere av denne artikkelen] (2023). Adaptive protein evolution through length variation of short tandem repeats in Arabidopsis. Science Advances. ISSN 2375-2548. 9(12), s. 1–10. doi: 10.1126/sciadv.add6960. Fulltekst i vitenarkiv
• Theissinger, Kathrin; Fernandes, Carlos; Formenti, Giulio; Bista, Iliana; Berg, Paul Ragnar & Bleidorn, Christoph [Vis alle 55 forfattere av denne artikkelen] (2023). How genomics can help biodiversity conservation. Trends in Genetics. ISSN 0168-9525. 39(7), s. 545–559. doi: 10.1016/j.tig.2023.01.005. Fulltekst i vitenarkiv Vis sammendrag

  The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics.

• Bjørnestad, Synne Arstad; Solbakken, Monica Hongrø; Jakobsen, Kjetill Sigurd; Jentoft, Sissel; Bakke, Oddmund & Progida, Cinzia (2023). Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 11, s. 1–15. doi: 10.3389/fcell.2023.1050323. Fulltekst i vitenarkiv
• Dharmarajan, Guha; Li, Ruiyun; Chanda, Emmanuel; Dean, Katharine Rose; Dirzo, Rodolfo & Jakobsen, Kjetill Sigurd [Vis alle 12 forfattere av denne artikkelen] (2022). The Animal Origin of Major Human Infectious Diseases: What Can Past Epidemics Teach Us About Preventing the Next Pandemic? Zoonoses. ISSN 2737-7474. 2(11). doi: 10.15212/ZOONOSES-2021-0028.
• Formenti, Giulio; Theissinger, Kathrin; Fernandes, Carlos; Bista, Iliana; Bombarely, Aureliano & Bleidorn, Christoph [Vis alle 59 forfattere av denne artikkelen] (2022). The era of reference genomes in conservation genomics. Trends in Ecology & Evolution. ISSN 0169-5347. 37(3), s. 197–202. doi: 10.1016/j.tree.2021.11.008. Fulltekst i vitenarkiv
• Nilsson, Pernille; Ravinet, Mark; Cui, Yujun; Berg, Paul Ragnar; Zhang, Yujiang & Guo, Rong [Vis alle 17 forfattere av denne artikkelen] (2022). Polygenic plague resistance in the great gerbil uncovered by population sequencing. PNAS Nexus. ISSN 2752-6542. 1(5). doi: 10.1093/pnasnexus/pgac211.
• Martinez Garcia, Lourdes; Ferrari, Giada; Hufthammer, Anne Karin; Jakobsen, Kjetill Sigurd; Jentoft, Sissel & Barrett, James Harold [Vis alle 7 forfattere av denne artikkelen] (2022). Ancient DNA reveals a southern presence of the Northeast Arctic cod during the Holocene. Biology Letters. ISSN 1744-9561. 18(5). doi: 10.1098/rsbl.2022.0021. Fulltekst i vitenarkiv
• Sætre, Camilla Lo Cascio; Rönkä, Katja; Ravinet, Mark; Vitulano, Severino; Caldarella, Matteo & Procházka, Petr [Vis alle 13 forfattere av denne artikkelen] (2022). Genomic consequences of range expansion and colonisation in the reed warbler (Acrocephalus scirpaceus). bioRxiv. ISSN 2692-8205. doi: 10.1101/2022.11.28.518135.
• Martinez Garcia, Lourdes; Ferrari, Giada; Cuevas, Angelica; Atmore, Lane Margaret; López-Arias, Begoña & Culling, Mark [Vis alle 18 forfattere av denne artikkelen] (2022). Ancient DNA evidence for the ecological globalization of cod fishing in medieval and post-medieval Europe. Proceedings of the Royal Society of London. Biological Sciences. ISSN 0962-8452. 289(1985). doi: 10.1098/rspb.2022.1107. Fulltekst i vitenarkiv
• Taugbøl, Annette; Solbakken, Monica Hongrø; Jakobsen, Kjetill Sigurd & Vøllestad, Leif Asbjørn (2022). Salinity-induced transcriptome profiles in marine and freshwater threespine stickleback after an abrupt 6-hour exposure. Ecology and Evolution. ISSN 2045-7758. 12(10). doi: 10.1002/ece3.9395. Fulltekst i vitenarkiv
• Guslund, Naomi Croft; Krabberød, Anders Kristian; Nørstebø, Simen Foyn; Solbakken, Monica Hongrø; Jakobsen, Kjetill Sigurd & Johansen, Finn-Eirik [Vis alle 7 forfattere av denne artikkelen] (2022). Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing. Communications Biology. ISSN 2399-3642. 5:689(1), s. 1–9. doi: 10.1038/s42003-022-03645-w. Fulltekst i vitenarkiv
• Matschiner, Michael; Barth, Julia Maria Isis; Tørresen, Ole K.; Star, Bastiaan; Baalsrud, Helle Tessand & Brieuc, Marine Servane Ono [Vis alle 10 forfattere av denne artikkelen] (2022). Supergene origin and maintenance in Atlantic cod. Nature Ecology and Evolution. ISSN 2397-334X. 6(4), s. 469–481. doi: 10.1038/s41559-022-01661-x. Fulltekst i vitenarkiv
• Lewin, Harris A.; Richards, Stephen; Aiden, Erez Lieberman; Allende, Miguel L.; Archibald, John M. & Bálint, Miklós [Vis alle 85 forfattere av denne artikkelen] (2022). The Earth BioGenome Project 2020: Starting the clock. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 119(4). doi: 10.1073/pnas.2115635118. Fulltekst i vitenarkiv
• Formenti, Giulio & Jakobsen, Kjetill Sigurd (2021). Complete vertebrate mitogenomes reveal widespread repeats and gene duplications. Genome Biology. ISSN 1465-6906. 22. doi: 10.1186/s13059-021-02336-9.
• Sætre, Camilla Lo Cascio; Eroukhmanoff, Fabrice; Rönkä, Katja; Kluen, Edward; Thorogood, Rose & Torrance, James [Vis alle 12 forfattere av denne artikkelen] (2021). A Chromosome-Level Genome Assembly of the Reed Warbler (Acrocephalus scirpaceus). Genome Biology and Evolution (GBE). ISSN 1759-6653. 13(9), s. 1–7. doi: 10.1093/gbe/evab212. Fulltekst i vitenarkiv
• Ferrari, Giada; Atmore, Lane Margaret; Jentoft, Sissel; Jakobsen, Kjetill Sigurd; Makowiecki, Daniel & Barrett, James [Vis alle 7 forfattere av denne artikkelen] (2021). An accurate assignment test for extremely low-coverage whole-genome sequence data. Molecular Ecology Resources. ISSN 1755-098X. s. 1–15. doi: 10.1111/1755-0998.13551. Fulltekst i vitenarkiv
• Pinsky, Malin L.; Eikeset, Anne Maria; Helmerson, Cecilia Jenny Margareta Thomas; Bradbury, Ian R.; Bentzen, Paul & Morris, Corey [Vis alle 17 forfattere av denne artikkelen] (2021). Genomic stability through time despite decades of exploitation in cod on both sides of the Atlantic. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(15). doi: 10.1073/pnas.2025453118. Fulltekst i vitenarkiv
• Reinar, William Brynildsen; Olsson, Vilde; Reitan, Trond; Jakobsen, Kjetill Sigurd & Butenko, Melinka Alonso (2021). Length variation in short tandem repeats affects gene expression in natural populations of Arabidopsis thaliana. The Plant Cell. ISSN 1040-4651. 33(7), s. 2221–2234. doi: 10.1093/plcell/koab107. Fulltekst i vitenarkiv
• Kersten, Oliver; Star, Bastiaan; Leigh, Deborah M.; Anker-Nilssen, Tycho; Strøm, Hallvard & Danielsen, Jóhannis [Vis alle 17 forfattere av denne artikkelen] (2021). Complex population structure of the Atlantic puffin revealed by whole genome analyses. Communications Biology. ISSN 2399-3642. 4. doi: 10.1038/s42003-021-02415-4. Fulltekst i vitenarkiv Vis sammendrag

  The factors underlying gene flow and genomic population structure in vagile seabirds are notoriously difficult to understand due to their complex ecology with diverse dispersal barriers and extensive periods at sea. Yet, such understanding is vital for conservation management of seabirds that are globally declining at alarming rates. Here, we elucidate the population structure of the Atlantic puffin (Fratercula arctica) by assembling its reference genome and analyzing genome-wide resequencing data of 72 individuals from 12 colonies. We identify four large, genetically distinct clusters, observe isolation-by-distance between colonies within these clusters, and obtain evidence for a secondary contact zone. These observations disagree with the current taxonomy, and show that a complex set of contemporary biotic factors impede gene flow over different spatial scales. Our results highlight the power of whole genome data to reveal unexpected population structure in vagile marine seabirds and its value for seabird taxonomy, evolution and conservation.

• Martinez Garcia, Lourdes; Ferrari, Giada; Oosting, Tom; Ballantyne, Rachel; van der Jagt, Inge & Ystgaard, Ingrid [Vis alle 20 forfattere av denne artikkelen] (2021). Historical demographic processes dominate genetic variation in ancient Atlantic cod mitogenomes. Frontiers in Ecology and Evolution. ISSN 2296-701X. 9, s. 1–14. doi: 10.3389/fevo.2021.671281. Fulltekst i vitenarkiv
• Croft, Naomi; Solbakken, Monica Hongrø; Brieuc, Marine Servane Ono; Jentoft, Sissel; Jakobsen, Kjetill Sigurd & Qiao, Shuo Wang (2020). Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.559555.
• Jin, Xingkun; Morro, Bernat; Tørresen, Ole K.; Moiche, Visila; Solbakken, Monica Hongrø & Jakobsen, Kjetill Sigurd [Vis alle 8 forfattere av denne artikkelen] (2020). Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Frontiers in Immunology. ISSN 1664-3224. 11. doi: 10.3389/fimmu.2020.609456.
• Riiser, Even Sannes; Haverkamp, Thomas Hendricus Augustus; Varadharajan, Srinidhi; Borgan, Ørnulf; Jakobsen, Kjetill Sigurd & Jentoft, Sissel [Vis alle 7 forfattere av denne artikkelen] (2020). Metagenomic Shotgun Analyses Reveal Complex Patterns of Intra- and Interspecific Variation in the Intestinal Microbiomes of Codfishes. Applied and Environmental Microbiology. ISSN 0099-2240. 86(6), s. 1–16. doi: 10.1128/AEM.02788-19.
• Cui, Yujun; Schmid, Boris Valentijn; Cao, Hanli; Dai, Xiang; Du, Zhongmin & Easterday, William Ryan [Vis alle 24 forfattere av denne artikkelen] (2020). Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment. Nature Communications. ISSN 2041-1723. 11, s. 1–8. doi: 10.1038/s41467-019-14099-w. Fulltekst i vitenarkiv
• Nilsson, Pernille; Solbakken, Monica Hongrø; Schmid, Boris Valentijn; Orr, Russell; Lv, Ruichen & Cui, Yujun [Vis alle 14 forfattere av denne artikkelen] (2020). The Genome of the Great Gerbil Reveals Species-Specific Duplication of an MHCII Gene. Genome Biology and Evolution (GBE). ISSN 1759-6653. 12(2), s. 3832–3849. doi: 10.1093/gbe/evaa008. Fulltekst i vitenarkiv
• Varadharajan, Srinidhi; Rastas, Pasi; Löytynoja, Ari; Matschiner, Michael; Calboli, Federico C. F. & Guo, Baocheng [Vis alle 9 forfattere av denne artikkelen] (2019). A High-Quality Assembly of the Nine-Spined Stickleback (Pungitius pungitius) Genome . Genome Biology and Evolution (GBE). ISSN 1759-6653. 11(11), s. 3291–3308. doi: 10.1093/gbe/evz240. Fulltekst i vitenarkiv
• Tørresen, Ole K.; Star, Bastiaan; Mier, Pablo; Andrade-Navarro, Miguel A.; Bateman, Alex & Jarnot, Patryk [Vis alle 13 forfattere av denne artikkelen] (2019). Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases. Nucleic Acids Research (NAR). ISSN 0305-1048. 47(21), s. 10994–11006. doi: 10.1093/nar/gkz841. Fulltekst i vitenarkiv
• Solbakken, Monica Hongrø; Jentoft, Sissel; Reitan, Trond; Mikkelsen, Helene; Gregers, Tone Fredsvik & Bakke, Oddmund [Vis alle 8 forfattere av denne artikkelen] (2019). Disentangling the immune response and host-pathogen interactions in Francisella noatunensis infected Atlantic cod. Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics. ISSN 1744-117X. 30, s. 333–346. doi: 10.1016/j.cbd.2019.04.004. Fulltekst i vitenarkiv
• Solbakken, Monica Hongrø; Jentoft, Sissel; Reitan, Trond; Mikkelsen, Helene; Jakobsen, Kjetill Sigurd & Seppola, Marit (2019). Whole transcriptome analysis of the Atlantic cod vaccine response reveals subtle changes in adaptive immunity. Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics. ISSN 1744-117X. 31:100597, s. 1–12. doi: 10.1016/j.cbd.2019.100597. Fulltekst i vitenarkiv
• Musilova, Zuzana; Cortesi, Fabio; Matschiner, Michael; Davies, Wayne I. L.; Patel, Jagdish Suresh & Stieb, Sara M. [Vis alle 18 forfattere av denne artikkelen] (2019). Vision using multiple distinct rod opsins in deep-sea fishes. Science. ISSN 0036-8075. 364(6440), s. 588–592. doi: 10.1126/science.aav4632.
• Riiser, Even Sannes; Haverkamp, Thomas Hendricus Augustus; Varadharajan, Srinidhi; Borgan, Ørnulf; Jakobsen, Kjetill Sigurd & Jentoft, Sissel [Vis alle 7 forfattere av denne artikkelen] (2019). Switching on the light: using metagenomic shotgun sequencing to characterize the intestinal microbiome of Atlantic cod. Environmental Microbiology. ISSN 1462-2912. 21(7), s. 2576–2594. doi: 10.1111/1462-2920.14652. Fulltekst i vitenarkiv
• Bråte, Jon; Fuss, Janina; Mehrotra, Shruti; Jakobsen, Kjetill Sigurd & Klaveness, Dag (2019). Draft genome assembly and transcriptome sequencing of the golden algae Hydrurus foetidus (Chrysophyceae). F1000 Research. ISSN 2046-1402. 8(401), s. 1–12. doi: 10.12688/f1000research.16734.3. Fulltekst i vitenarkiv Vis sammendrag

  Hydrurus foetidus is a freshwater alga belonging to the phylum Heterokonta. It thrives in cold rivers in polar and high alpine regions. It has several morphological traits reminiscent of single-celled eukaryotes, but can also form macroscopic thalli. Despite its ability to produce polyunsaturated fatty acids, its life under cold conditions and its variable morphology, very little is known about its genome and transcriptome. Here, we present an extensive set of next-generation sequencing data, including genomic short reads from Illumina sequencing and long reads from Nanopore sequencing, as well as full length cDNAs from PacBio IsoSeq sequencing and a small RNA dataset (smaller than 200 bp) sequenced with Illumina. We combined this data with, to our knowledge, the first draft genome assembly of a chrysophyte algae. The assembly consists of 5069 contigs to a total assembly size of 171 Mb and a 77% BUSCO completeness. The new data generated here may contribute to a better understanding of the evolution and ecological roles of chrysophyte algae, as well as to resolve the branching patterns within the Heterokonta.

• Barth, Julia Maria Isis; Villegas-Ríos, David; Freitas, Carla; Moland, Even; Star, Bastiaan & André, Carl [Vis alle 15 forfattere av denne artikkelen] (2019). Disentangling structural genomic and behavioral barriers in a sea of connectivity. Molecular Ecology. ISSN 0962-1083. 28(6), s. 1394–1411. doi: 10.1111/mec.15010. Fulltekst i vitenarkiv
• Malmstrøm, Martin; Britz, Ralf; Matschiner, Michael; Tørresen, Ole K.; Hadiaty, Renny Kurnia & Yaakob, Norsham [Vis alle 10 forfattere av denne artikkelen] (2018). The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome Biology and Evolution (GBE). ISSN 1759-6653. 10(4), s. 1088–1103. doi: 10.1093/gbe/evy058. Fulltekst i vitenarkiv
• Varadharajan, Srinidhi; Sandve, Simen Rød; Gillard, Gareth Benjamin; Tørresen, Ole K.; Mulugeta, Teshome Dagne & Hvidsten, Torgeir Rhoden [Vis alle 11 forfattere av denne artikkelen] (2018). The grayling genome reveals selection on gene expression regulation after whole-genome duplication. Genome Biology and Evolution (GBE). ISSN 1759-6653. 10(10), s. 2785–2800. doi: 10.1093/gbe/evy201. Fulltekst i vitenarkiv
• Hoff, Siv Nam Khang; Baalsrud, Helle Tessand; Tooming-Klunderud, Ave; Skage, Morten; Richmond, Todd & Obernosterer, Gregor [Vis alle 10 forfattere av denne artikkelen] (2018). Long‐read sequence capture of the haemoglobin gene clusters across codfish species. Molecular Ecology Resources. ISSN 1755-098X. 19(1), s. 245–259. doi: 10.1111/1755-0998.12955.
• Riiser, Even Sannes; Haverkamp, Thomas Hendricus Augustus; Borgan, Ørnulf; Jakobsen, Kjetill Sigurd; Jentoft, Sissel & Star, Bastiaan (2018). A single vibrionales 16S rRNA oligotype dominates the intestinal microbiome in two geographically separated Atlantic cod populations. Frontiers in Microbiology. ISSN 1664-302X. 9. doi: 10.3389/fmicb.2018.01561. Fulltekst i vitenarkiv
• Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K.; Lille-Langøy, Roger; Puntervoll, Pål & Goldstone, Jared V. [Vis alle 10 forfattere av denne artikkelen] (2018). Independent losses of a xenobiotic receptor across teleost evolution. Scientific Reports. ISSN 2045-2322. 8, s. 1–13. doi: 10.1038/s41598-018-28498-4. Fulltekst i vitenarkiv
• Vader, Anna; Laughinghouse IV, Haywood; Griffiths, Colin; Jakobsen, Kjetill Sigurd & Gabrielsen, Tove M. (2018). Proton-pumping rhodopsins are abundantly expressed by microbial eukaryotes in a high-Arctic fjord. Environmental Microbiology. ISSN 1462-2912. 20(2), s. 890–902. doi: 10.1111/1462-2920.14035.
• Tørresen, Ole K.; Brieuc, Marine Servane; Solbakken, Monica Hongrø; Sørhus, Elin; Nederbragt, Alexander Johan & Jakobsen, Kjetill Sigurd [Vis alle 9 forfattere av denne artikkelen] (2018). Genomic architecture of haddock (Melanogrammus aeglefinus) shows expansions of innate immune genes and short tandem repeats. BMC Genomics. ISSN 1471-2164. 19(240), s. 1–17. doi: 10.1186/s12864-018-4616-y. Fulltekst i vitenarkiv
• Jørgensen, Tor Erik; Karlsen, Bård Ove; Emblem, Åse; Breines, Ragna; Andreassen, morten & Rounge, Trine Ballestad [Vis alle 15 forfattere av denne artikkelen] (2018). Mitochondrial genome variation of Atlantic cod. BMC Research Notes. ISSN 1756-0500. 11:397, s. 1–7. doi: 10.1186/s13104-018-3506-3. Fulltekst i vitenarkiv
• Baalsrud, Helle Tessand; Tørresen, Ole Kristian; Solbakken, Monica Hongrø; Salzburger, Walter; Hanel, Reinhold & Jakobsen, Kjetill Sigurd [Vis alle 7 forfattere av denne artikkelen] (2017). De Novo Gene Evolution of Antifreeze Glycoproteins in Codfishes Revealed by Whole Genome Sequence Data. Molecular Biology and Evolution (MBE). ISSN 0737-4038. 35(3), s. 593–606. doi: 10.1093/molbev/msx311. Fulltekst i vitenarkiv
• Berg, Paul Ragnar; Star, Bastiaan; Pampoulie, Christophe; Bradbury, Ian R.; Bentzen, Paul & Hutchings, Jeffrey [Vis alle 8 forfattere av denne artikkelen] (2017). Trans-oceanic genomic divergence of Atlantic cod ecotypes is associated with large inversions. Heredity. ISSN 0018-067X. 119, s. 418–428. doi: 10.1038/hdy.2017.54. Fulltekst i vitenarkiv
• Baalsrud, Helle Tessand; Voje, Kjetil L.; Tørresen, Ole Kristian; Solbakken, Monica Hongrø; Matschiner, Michael & Malmstrøm, Martin [Vis alle 10 forfattere av denne artikkelen] (2017). Evolution of Hemoglobin Genes in Codfishes Influenced by Ocean Depth. Scientific Reports. ISSN 2045-2322. 7, s. 1–10. doi: 10.1038/s41598-017-08286-2. Fulltekst i vitenarkiv Vis sammendrag

  Understanding the genetic basis of adaptation is one of the main enigmas of evolutionary biology. Among vertebrates, hemoglobin has been well documented as a key trait for adaptation to different environments. Here, we investigate the role of hemoglobins in adaptation to ocean depth in the diverse teleost order Gadiformes, with species distributed at a wide range of depths varying in temperature, hydrostatic pressure and oxygen levels. Using genomic data we characterized the full hemoglobin (Hb) gene repertoire for subset of species within this lineage. We discovered a correlation between expanded numbers of Hb genes and ocean depth, with the highest numbers in species occupying shallower, epipelagic regions. Moreover, we demonstrate that the Hb genes have functionally diverged through diversifying selection. Our results suggest that the more variable environment in shallower water has led to selection for a larger Hb gene repertoire and that Hbs have a key role in adaptive processes in marine environments.

• Barth, Julia Maria Isis; Berg, Paul Ragnar; Jonsson, Per R; Bonanomi, Sara; Corell, Hanna & Hemmer-Hansen, Jakob [Vis alle 16 forfattere av denne artikkelen] (2017). Genome architecture enables local adaptation of Atlantic cod despite high connectivity. Molecular Ecology. ISSN 0962-1083. 26(17), s. 4452–4466. doi: 10.1111/mec.14207. Fulltekst i vitenarkiv
• Star, Bastiaan; Boessenkool, Sanne; Gondek, Agata Teresa; Nikulina, Elena A.; Hufthammer, Anne Karin & Pampoulie, Christophe [Vis alle 16 forfattere av denne artikkelen] (2017). Ancient DNA reveals the Arctic origin of Viking Age cod from Haithabu, Germany. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 114(34), s. 9152–9157. doi: 10.1073/pnas.1710186114. Fulltekst i vitenarkiv
• Solbakken, Monica Hongrø; Voje, Kjetil L.; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2017). Linking species habitat and past palaeoclimatic events to evolution of the teleost innate immune system. Proceedings of the Royal Society of London. Biological Sciences. ISSN 0962-8452. 284(1853), s. 1–9. doi: 10.1098/rspb.2016.2810. Fulltekst i vitenarkiv Vis sammendrag

  Host-intrinsic factors as well as environmental changes are known to be strong evolutionary drivers defining the genetic foundation of immunity. Using a novel set of teleost genomes and a time-calibrated phylogeny, we here investigate the family of Toll-like receptor (TLR) genes and address the underlying evolutionary processes shaping the diversity of the first-line defence. Our findings reveal remarkable flexibility within the evolutionary design of teleost innate immunity characterized by prominent TLR gene losses and expansions. In the order of Gadiformes, expansions correlate with the loss of major histocompatibility complex class II (MHCII) and diversifying selection analyses support that this has fostered new immunological innovations in TLRs within this lineage. In teleosts overall, TLRs expansions correlate with species latitudinal distributions and maximum depth. By contrast, lineage-specific gene losses overlap with well-described changes in palaeoclimate (global ocean anoxia) and past Atlantic Ocean geography. In conclusion, we suggest that the evolvability of the teleost immune system has most likely played a prominent role in the survival and successful radiation of this lineage.

• Malmstrøm, Martin; Matschiner, Michael; Tørresen, Ole Kristian; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2017). Whole genome sequencing data and de novo draft assemblies for 66 teleost species. Scientific Data. ISSN 2052-4463. 4, s. 1–13. doi: 10.1038/sdata.2016.132. Fulltekst i vitenarkiv
• Tørresen, Ole Kristian; Star, Bastiaan; Jentoft, Sissel; Reinar, William Brynildsen; Grove, Harald & Miller, Jason R. [Vis alle 16 forfattere av denne artikkelen] (2017). An improved genome assembly uncovers prolific tandem repeats in Atlantic cod. BMC Genomics. ISSN 1471-2164. 18, s. 1–23. doi: 10.1186/s12864-016-3448-x. Fulltekst i vitenarkiv
• Solbakken, Monica Hongrø; Rise, Matthew L.; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2016). Successive losses of central immune genes characterize the Gadiformes’ alternate immunity. Genome Biology and Evolution (GBE). ISSN 1759-6653. 8(11), s. 3508–3515. doi: 10.1093/gbe/evw250. Fulltekst i vitenarkiv Vis sammendrag

  Great genetic variability among teleost immunomes, with gene losses and expansions of central adaptive and innate components, has been discovered through genome sequencing over the last few years. Here, we demonstrate that the innate Myxovirus resistance gene (Mx) is lost from the ancestor of Gadiformes and the closely related Stylephorus chordatus, thus predating the loss of Major Histocompatibility Complex class II (MHCII) in Gadiformes. Although the functional implication of Mx loss is still unknown, we demonstrate that this loss is one of several ancient events appearing in successive order throughout the evolution of teleost immunity. In particular, we find that the loss of Toll-like receptor 5 predates the loss of Mx involving the entire Paracanthopterygii lineage. Using a time-calibrated phylogeny, we show that loss of MHCII and Mx overlap with major paleoclimatic and geological events indicating thatthese genetic changes were adaptive responses to the changing environment at the time.

• Malmstrøm, Martin; Matschiner, Michael; Tørresen, Ole Kristian; Star, Bastiaan; Snipen, Lars-Gustav & Hansen, Thomas F [Vis alle 13 forfattere av denne artikkelen] (2016). Evolution of the immune system influences speciation rates in teleost fishes. Nature Genetics. ISSN 1061-4036. 48(10), s. 1204–1210. doi: 10.1038/ng.3645. Fulltekst i vitenarkiv
• Hicks, Natalie; Vik, Unni; Taylor, Peter; Ladoukakis, Efthymios; Park, Joonsang & Kolisis, Frangiskos [Vis alle 7 forfattere av denne artikkelen] (2016). Using Prokaryotes for Carbon Capture Storage. Trends in Biotechnology. ISSN 0167-7799. 35(1), s. 22–32. doi: 10.1016/j.tibtech.2016.06.011. Vis sammendrag

  Geological storage of CO2 is a fast-developing technology that can mitigate rising carbon emissions. However, there are environmental concerns with the long-term storage and implications of a leak from a carbon capture storage (CCS) site. Traditional monitoring lacks clear protocols and relies heavily on physical methods. Here, we discuss the potential of biotechnology, focusing on microbes with a natural ability to utilize and assimilate CO2 through different metabolic pathways. We propose the use of natural microbial communities for CCS monitoring and CO2 utilization, and, with examples, demonstrate how synthetic biology may maximize CO2 uptake within and above storage sites. An integrated physical and biological approach, combined with metagenomics data and biotechnological advances, will enhance CO2 sequestration and prevent large-scale leakages.

• Gante, Hugo F; Matschiner, Michael; Malmstrøm, Martin; Jakobsen, Kjetill Sigurd; Jentoft, Sissel & Salzburger, Walter (2016). Genomics of speciation and introgression in Princess cichlid fishes from Lake Tanganyika. Molecular Ecology. ISSN 0962-1083. 25(24), s. 6143–6161. doi: 10.1111/mec.13767. Vis sammendrag

  How variation in the genome translates into biological diversity and new species originate has endured as the mystery of mysteries in evolutionary biology. African cichlid fishes are prime model systems to address speciation-related questions for their remarkable taxonomic and phenotypic diversity, and the possible role of gene flow in this process. Here, we capitalize on genome sequencing and phylogenomic analyses to address the relative impacts of incomplete lineage sorting, introgression and hybrid speciation in the Neolamprologus savoryi-complex (the ‘Princess cichlids’) from Lake Tanganyika. We present a time-calibrated species tree based on whole-genome sequences and provide strong evidence for incomplete lineage sorting in the early phases of diversification and multiple introgression events affecting different stages. Importantly, we find that the Neolamprologus chromosomes show centre-to-periphery biases in nucleotide diversity, sequence divergence, GC content, incomplete lineage sorting and rates of introgression, which are likely modulated by recombination density and linked selection. The detection of heterogeneous genomic landscapes has strong implications on the genomic mechanisms involved in speciation. Collinear chromosomal regions can be protected from gene flow and harbour incompatibility genes if they reside in lowly recombining regions, and coupling can evolve between nonphysically linked genomic regions (chromosome centres in particular). Simultaneously, higher recombination towards chromosome peripheries makes these more dynamic, evolvable regions where adaptation polymorphisms have a fertile ground. Hence, differences in genome architecture could explain the levels of taxonomic and phenotypic diversity seen in taxa with collinear genomes and might have contributed to the spectacular cichlid diversity observed today.

• Star, Bastiaan; Tørresen, Ole Kristian; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Pampoulie, Christophe & Jentoft, Sissel (2016). Genomic characterization of the Atlantic cod sex-locus. Scientific Reports. ISSN 2045-2322. 6, s. 1–9. doi: 10.1038/srep31235. Fulltekst i vitenarkiv
• Tørresen, Ole Kristian; Rise, Matthew L.; Jin, Xingkun; Star, Bastiaan; MacKenzie, Simon & Jakobsen, Kjetill Sigurd [Vis alle 8 forfattere av denne artikkelen] (2016). An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming. I MacKenzie, Simon & Jentoft, Sissel (Red.), Genomics in Aquaculture. Elsevier. ISSN 9780128014189. s. 45–72. doi: 10.1016/B978-0-12-801418-9.00003-2.
• Tørresen, Ole Kristian; Star, Bastiaan; Jentoft, Sissel; Jakobsen, Kjetill Sigurd & Nederbragt, Alexander Johan (2016). The new era of genome sequencing using high-throughput sequencing technology: Generation of the first version of the Atlantic cod genome. I MacKenzie, Simon & Jentoft, Sissel (Red.), Genomics in Aquaculture. Elsevier. ISSN 9780128014189. s. 1–20. doi: 10.1016/B978-0-12-801418-9.00001-9.
• Lien, Sigbjørn; Koop, Ben F; Sandve, Simen Rød; Miller, Jason R.; Kent, Matthew Peter & Nome, Torfinn [Vis alle 45 forfattere av denne artikkelen] (2016). The Atlantic salmon genome provides insights into rediploidization. Nature. ISSN 0028-0836. 533(7602), s. 200–205. doi: 10.1038/nature17164. Fulltekst i vitenarkiv
• Solbakken, Monica Hongrø; Tørresen, Ole Kristian; Nederbragt, Alexander Johan; Seppola, Marit; Gregers, Tone Fredsvik & Jakobsen, Kjetill Sigurd [Vis alle 7 forfattere av denne artikkelen] (2016). Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions. Scientific Reports. ISSN 2045-2322. 6. doi: 10.1038/srep25211. Fulltekst i vitenarkiv Vis sammendrag

  Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition receptor (PRR) family of Toll-like receptors (TLR). In a comparative genomic setting, using an improved version of the genome, we characterize PRRs in Atlantic cod with emphasis on TLRs demonstrating the loss of TLR1/6, TLR2 and TLR5 and expansion of TLR7, TLR8, TLR9, TLR22 and TLR25. We find that Atlantic cod TLR expansions are strongly influenced by diversifying selection likely to increase the detectable ligand repertoire through neo- and subfunctionalization. Using RNAseq we find that Atlantic cod TLRs display likely tissue or developmental stage-specific expression patterns. In a broader perspective, a comprehensive vertebrate TLR phylogeny reveals that the Atlantic cod TLR repertoire is extreme with regards to losses and expansions compared to other teleosts. In addition we identify a substantial shift in TLR repertoires following the evolutionary transition from an aquatic vertebrate (fish) to a terrestrial (tetrapod) life style. Collectively, our findings provide new insight into the function and evolution of TLRs in Atlantic cod as well as the evolutionary history of vertebrate innate immunity.

• Berg, Paul Ragnar; Star, Bastiaan; Pampoulie, Christophe; Sodeland, Marte; Barth, Julia Maria Isis & Knutsen, Halvor [Vis alle 8 forfattere av denne artikkelen] (2016). Three chromosomal rearrangements promote genomic divergence between migratory and stationary ecotypes of Atlantic cod. Scientific Reports. ISSN 2045-2322. 6, s. 1–12. doi: 10.1038/srep23246. Fulltekst i vitenarkiv
• Marcussen, Thomas; Heier, Lise; Brysting, Anne Krag; Oxelman, Bengt & Jakobsen, Kjetill Sigurd (2015). From gene trees to a dated allopolyploid network: insights from the angiosperm genus Viola (Violaceae). Systematic Biology. ISSN 1063-5157. 64(1), s. 84–101. doi: 10.1093/sysbio/syu071.
• Sandve, Simen Rød; Marcussen, Thomas; Mayer, Klaus F X; Jakobsen, Kjetill Sigurd; Heier, Lise & Steuernagel, Burkhard [Vis alle 8 forfattere av denne artikkelen] (2015). Chloroplast phylogeny of Triticum/Aegilops species is not incongruent with an ancient homoploid hybrid origin of the ancestor of the bread wheat D-genome. New Phytologist. ISSN 0028-646X. 208(1), s. 9–10. doi: 10.1111/nph.13487.
• Stüken, Anke; Riobo, Pilar; Franco, Jose; Jakobsen, Kjetill Sigurd; Guillou, L & Figueroa, Rosa (2015). Paralytic shellfish toxin content is related to genomic sxtA4 copy number in Alexandrium minutum strains. Frontiers in Microbiology. ISSN 1664-302X. 6, s. 1–10. doi: 10.3389/fmicb.2015.00404. Fulltekst i vitenarkiv
• Berg, Paul Ragnar; Jentoft, Sissel; Star, Bastiaan; Ring, Kristoffer Hofaker; Knutsen, Halvor & Lien, Sigbjørn [Vis alle 8 forfattere av denne artikkelen] (2015). Adaptation to low salinity promotes genomic divergence in Atlantic Cod (Gadus morhua L.). Genome Biology and Evolution (GBE). ISSN 1759-6653. 7(6), s. 1644–1663. doi: 10.1093/gbe/evv093. Fulltekst i vitenarkiv
• Xiao, Xi; Sogge, Hanne; Lagesen, Karin; Tooming-Klunderud, Ave; Jakobsen, Kjetill Sigurd & Rohrlack, Thomas (2014). Use of high throughput sequencing and light microscopy show contrasting results in a study of phytoplankton occurrence in a freshwater environment. PLOS ONE. ISSN 1932-6203. 9(8). doi: 10.1371/journal.pone.0106510. Fulltekst i vitenarkiv

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• Hoff, Siv Nam Khang; Maurstad, Marius Filomeno; Alan, Le Moan; Ravinet, Mark; Durant, Joël & Tørresen, Ole K. [Vis alle 18 forfattere av denne artikkelen] (2023). Identification of multiple chromosomal inversions and fusions in a keystone Arctic species with high gene flow.
• Hoff, Siv Nam Khang; Maurstad, Marius Filomeno; Le Moan, Alan; Ravinet, Mark; Durant, Joël & Tørresen, Ole Kristian [Vis alle 18 forfattere av denne artikkelen] (2023). Identification of multiple chromosomal inversions and fusions in a keystone Arctic species with high gene flow.
• Marcussen, Thomas & Jakobsen, Kjetill Sigurd (2023). En nasjonal dugnad for å kartlegge genomene til alle artene i Norge – EBP-Nor. Biolog. ISSN 0801-0722. 41(1), s. 6–12.
• Tørresen, Ole K.; Baalsrud, Helle Tessand; Sandve, Simen Rød & Jakobsen, Kjetill Sigurd (2022). Bioinfomatic approaches for EBP-Nor.
• Konstantinidis, Ioannis; Sætrom, Pål; Brieuc, Marine Servane Ono; Jakobsen, Kjetill Sigurd; Liedtke, Hannes & Pohlmann, Caroline [Vis alle 8 forfattere av denne artikkelen] (2021). DNA hydroxymethylation is linked to higher growth rate in Nile tilapia.
• Jakobsen, Kjetill Sigurd; Johansen, Finn-Eirik; Qiao, Shuo Wang; Asdal, Kristin; Druglitrø, Tone & Morsman, Silje Rebecca (2021). Torsken skrotet deler av immunforsvaret. Hva kan vi lære av det? Aftenposten Viten. ISSN 2464-3033.
• Stenseth, Nils Christian; Baalsrud, Helle Tessand; Jakobsen, Kjetill Sigurd; Brautaset, Trygve; Goksøyr, Anders & Jensen, Nina [Vis alle 9 forfattere av denne artikkelen] (2021). Havgenomet – bevaring og bærekraftig bruk av marine genetiske ressurser i Norge. I Rist, Therese & Elvevoll, Edel O. (Red.), Blått kompass - Stø kurs mot bærekraft i norske havnæringer. Senter for hav og Arktis. ISSN 978-82-93806-08-0.
• Görbitz, Carl Henrik; Jakobsen, Kjetill Sigurd; Sandve, Simen Rød; Goksøyr, Anders; Brautaset, Trygve & Jørgensen, Trond Ø. (2019). Den sjette masseutryddelse og Jordens DNA. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
• Jakobsen, Kjetill Sigurd (2019). The Norwegian Initiative for Biodiversity Genomics.
• Tørresen, Ole K.; Skrede, Inger; Sandve, Simen Rød; Jentoft, Sissel; Jakobsen, Kjetill Sigurd & Borge, Ole Johan (2018). Gendykk i norsk natur gir ny kunnskap. Genialt. ISSN 0804-225X. s. 16–18.
• Reinar, William Brynildsen; Tørresen, Ole K.; Matschiner, Michael; Jentoft, Sissel; Nederbragt, Alexander Johan & Jakobsen, Kjetill Sigurd (2018). The impact of repetitive DNA on speciation rates in teleost fish.
• Sandve, Simen Rød; Hvidsten, Torgeir Rhoden; Lien, Sigbjørn; Rori, Rohlfs; Jakobsen, Kjetill Sigurd & Nome, Torfinn [Vis alle 9 forfattere av denne artikkelen] (2017). Evolution after whole genome duplication - insights from the salmonids.
• Barth, Julia Maria Isis; Star, Bastiaan; Matschiner, Michael; André, Carl; Knutsen, Halvor & Bradbury, Ian [Vis alle 13 forfattere av denne artikkelen] (2017). Chromosomal rearrangements as barriers to homogenization in highly mobile fish.
• Barth, Julia Maria Isis; Star, Bastiaan; Matschiner, Michael; André, Carl; Knutsen, Halvor & Bradbury, Ian [Vis alle 13 forfattere av denne artikkelen] (2017). Chromosomal rearrangements as barriers to homogenization in highly mobile fish.
• Matschiner, Michael; Star, Bastiaan; Barth, Julia Maria Isis; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2017). Genomic rearrangements a phylogenetic approach.
• Rose, Carina; Torgersen, Eivind; Ørmen, Torfinn; Høiland, Klaus & Jakobsen, Kjetill Sigurd (2016). Hva er egentlig en art? [Internett]. http://forskning.no/2016/11/-biologi-hva-er-egentlig-en-art.
• Knudsen, Jonfinn B.; Reinar, William B. & Jakobsen, Kjetill Sigurd (2016). Evolutionary and functional importance of simple repeats in eukaryotic genomes.
• Eide, Marta; Puntervoll, Pål; Lille-Langøy, Roger; Goldstone, Jared V.; Tørresen, Ole Kristian & Nederbragt, Alexander Johan [Vis alle 11 forfattere av denne artikkelen] (2016). Chemical warfare in the marine environment: genomic survey of the Atlantic cod (Gadus morhua) defensome reveals the absence of an important xenosensor.
• Barth, Julia Maria Isis; Star, Bastiaan; Matschiner, Michael; Berg, Paul Ragnar; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2016). Ancient genomic variation separates Atlantic cod ecotypes; implications for management.
• Jakobsen, Kjetill Sigurd (2015). Store datamengder.
• Jakobsen, Kjetill Sigurd (2015). The Codfather - Toppforsker på fisketur.
• Baalsrud, Helle Tessand; Tørresen, Ole Kristian; Malmstrøm, Martin; Salzburger, Walter; Jakobsen, Kjetill Sigurd & Jentoft, Sissel (2015). The hemoglobin repertoire in the order of Gadiformes linked to depth adaptation.
• Star, Bastiaan; Jentoft, Sissel; Matschiner, Michael; Nederbragt, Alexander Johan; Kjesbu, Olav Sigurd & Berg, Paul Ragnar [Vis alle 12 forfattere av denne artikkelen] (2015). Does historic DNA provide genomic evidence for recent selection in Atlantic cod?
• Jakobsen, Kjetill Sigurd (2015). Scientists study teeth and gerbils to further understand plague.
• Nilsson, Pernille & Jakobsen, Kjetill Sigurd (2015). Pestbakterier fra jernalder og svartedauden analyseres i Norge. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
• Nilsson, Pernille & Jakobsen, Kjetill Sigurd (2015). Finner DNA-rester av pestbakterier fra svartedauden. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926.
• Jakobsen, Kjetill Sigurd (2014). Menneskeskapt kromosom puttet inn i levende sopp-celle.
• Jakobsen, Kjetill Sigurd (2014). Quicker and cheaper toxicity checking of mussels.
• Jakobsen, Kjetill Sigurd (2014). Amerikanere skaber kunstigt kromosom.
• Jakobsen, Kjetill Sigurd (2014). Raskere og billigere giftsjekk av blåskjell.
• Evjen, Tove Julie; Dick, Gunnar; Skogli, Erik Winther; Høiseth-Gilje, Kaja; Jakobsen, Kjetill Sigurd & Tasken, Kjetil (2017). Den digitale bioteknologien i Norge - Muligheter for verdiskaping, kompetansebehov og utfordringer i næringsutvikling. Senter for digitalt liv, Norge. ISSN 978-82-93591-00-9. Fulltekst i vitenarkiv
• Skage, Morten; Barth, Julia Maria Isis; Jentoft, Sissel; Øverli, Øyvind & Jakobsen, Kjetill Sigurd (2017). Genetisk bakgrunn hos ulv (Canis lupus) i Norge og Skandinavia. Universitetet i Oslo. Fulltekst i vitenarkiv Vis sammendrag

  Formålet med denne undersøkelsen var å identifisere mulige krysninger mellom hund og ulv i dagens skandinaviske ulvebestand. I tillegg ønsket vi å finne ut i hvor stor grad det er mulig å gjenkjenne innblanding av hund i ulvens arvemateriale (hybridisering og tilbake-krysninger). Metodene som vi har anvendt i undersøkelsen er dyrere og mer tidkrevende enn det dagens forvaltningsmetodikk legger opp til (mikrosatelittanalyse), men gir bedre oppløsning over hele arvemassen og muliggjør deteksjon av svake hybridsignaler. Analysene er basert på data fra hel-genomsekvensering av ulv (dagens skandinaviske bestand og andre ulv), historisk ulv (Nordreisa 1962, Dyrøy 1963, Målselv 1963, og Stor Elvdal 1964), ulvehund (tsjekkisk ulvehund), primitive hunderaser (dingo, basenji, tibetansk mastiff) og moderne hunderaser (boxer etc), alle med ulik geografisk opprinnelse. De norske individene som er sekvensert i denne undersøkelsen kommer alle fra svenske føderevir, men har lagt ut på vandring og blitt avlivet i Norge (Stange, Nord-Odal, Sykkylven, Elverum og Trysil), og inngikk i det som betraktes som en felles skandinavisk bestand. Våre analyser viser: ● Den skandinaviske bestanden grupperer sammen med andre europeiske ulver, og ulver fra Asia, kalt «old world gruppen» i PCA (bilag1) ● Nylig hybridisering mellom ulv og hund ble ikke påvist. ● Genetiske analyser indikerer historisk innblanding av hund i alle analyserte ulver, også i skandinavisk bestand, men det er ikke mer innslag av hund i skandinavisk bestand enn hva som er funnet i andre populasjoner.

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