Nettsider med emneord «bioinformatics»

Gene expression is regulated though long-range interactions with enhancer and silencer elements that come into close contact with promoter regions in three-dimensional (3D) space. However, the mechanism is not understood.

Our DNA is organized into spatially distinct compartments that affect important functions in the cell [1]. Thus, cell function depends not only on the linear arrangement of DNA elements but also on their three-dimensional (3D) organization. However, the mechanisms by which sub-nuclear compartments (See Figure.1) are structured and maintained, as well as what determines their composition, size and shape at various phases of the cell cycle remain substantially unknown.