The PhD defence will be partially digital, in Kristen Nygaards sal (5370), Ole-Johan Dahls hus and streamed directly using Zoom. The host of the session will moderate the technicalities while the chair of the defence will moderate the disputation.
Ex auditorio questions: the chair of the defence will invite the attending audience at Kristen Nygaards sal to ask ex auditorio questions.
Trial lecture
- Friday 12 August 2022, 11:15, in Kristen Nygaards sal (5370), Ole-Johan Dahls hus / Zoom
- Join the trial lecture
- Title: "AI in Personalized Medicine: Challenges and Opportunities"
Main research findings
Adaptive immune receptors are a part of the immune system that specifically recognizes threats like viruses, bacteria, and cancerous cells and mounts an immune response to neutralize them. Using high-throughput sequencing methods, it is possible to observe the receptors and apply machine learning algorithms on those data to diagnose disease better, earlier or test for more diseases from a single test sample. Furthermore, if we could determine the underlying immune receptor-disease recognition rules, we could computationally improve the design of therapeutics.
In this thesis, Milena Pavlović combines machine learning and software engineering to develop the immuneML platform for designing and benchmarking machine learning algorithms for immune receptor analysis. Together with colleagues, Milena used the platform to benchmark machine learning approaches and explored how changes in the distribution of various properties in this domain might affect immune receptor diagnostics using the causal inference framework.
Adjudication committee:
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Associate Professor Johannes Textor, Institute for Computing and Information Sciences, Radboud University, the Netherlands
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Dr. Adriana Tomic, Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), University of Oxford, United Kingdom
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Associate Professor Adín Ramírez Rivera, University of Oslo, Department of Informatics Norway
Supervisors
- Professor Geir Kjetil Sandve, Department of Informatics, UiO
- Professor Victor Greiff, Department of Immunology, UiO
- Professor Ludvig Magne Sollid, Department of Immunology, UiO
- Professor Torbjørn Rognes, Department of Informatics, UiO
Chair of defence
- Professor Petter Nielsen, University of Oslo, Department of informatics
Candidate contact information:
Contact information to Department: Pernille Adine Nordby