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A general method to design a more stable enzyme

The seminar will be held by Prof. Joel L. Sussman, Weizmann Institute of Science in Israel. He is studying the 3D structure/function of nervous system proteins. His findings may impact the treatment of neurological disorders, including Alzheimer's disease and autism.

Graphical demonstration of transformation of Human acetylcholinesterase (hAChE) to designed AChE (51 mutations) with about 2000 fold hicher bacterial expression levels.

Todays seminar

The seminar is the second department seminar this year and is held by Prof. Joel Sussman (Weizmann Institute of Science). He is studying the 3D structure/function of nervous system proteins, such as acetylcholinesterase (AChE), cholinesterase-like adhesion molecules (CLAMs), β-glucosidase, β-secretase, paraoxonase and intrinsically disordered proteins.

Although his research is curiosity driven, the findings may impact the treatment of neurological disorders, including Alzheimer's disease and autism.

Read more about Professor Joel Sussman and his work

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Figure: Graphical demonstration of transformation of Human acetylcholinesterase (hAChE) to designed AChE (51 mutations) with about 2000 fold hicher bacterial expression levels.

Lecture, coffee and cake 

All department seminar are open for all. The seminars are particularly interesting for student and academic staff. 

Short presentation of the department seminars

Our department seminar is a social and educational event, and we try to include all people from our department.

We start in the cantina for coffee and cakes at 14.15 and move into the auditorium for the lecture around 14.25-14.30.

The presentation should be approximately 30 minutes. There will be time for discussions after the presentation. The audience will be both students and employees at the department of Chemistry, with various chemistry backgrounds.

Some introduction to your field of expertise is therefore needed to make sure people from a completely different brand of chemistry can follow.

Tags: enzymologi, Neuroscience, Department of Chemistry
Published Mar. 31, 2023 1:28 PM - Last modified Mar. 31, 2023 1:43 PM