The Disputation will be live streamed for everyone else.
The livestream will be activated 15 minutes before the Defence starts.
Trial lecture
June 9th, 10:15 AM, Auditorium 3, Chemistry building
Trial lecture title:
“Overview of metal-free and metal-catalysed arylation methods”
The trial lecture will be live streamed for everyone else.
The livestream will be activated 15 minutes before the trial lecture starts.
Kreeringssammendrag/Conferral summary
Hydantoiner er viktige, organiske rammeverk som finnes i en rekke legemidler. Det er derfor behov for stadig bedre syntetiske verktøy for mer effektiv produksjon av disse. Denne avhandlingen har tatt for seg utviklingen av nye, synestetiske metoder for fremstillingen av hydantoiner.
Main research findings
Hydantoin is an organic framework of considerable chemical and biological interest as it is encountered in several drugs and natural products with biological activity. Access to synthetic tools for synthesis and modification of the hydantoin framework is therefore of importance both in academia and industry. The current synthetic methods used often include multiple steps, harsh conditions and toxic reagents, and thus have room for improvement.
In this work, development of new and improved synthetic processes that allow for more efficient and less toxic production of hydantoins and derivatives is presented. The concept of the methods is direct bond formation between (carbon-based) functional groups and a specific position in the hydantoin framework. It was discovered that the key to solve this challenging task was to use copper as a catalyst. The methods developed allows for synthesis of two different classes of substituted hydantoins, including structures previously not accessible.