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[2] S Kondrat, O Zimmermann, W Wiechert, E von Lieres, The effect of composition on diffusion of macromolecules in a crowded environment, Phys. Biol. 12, 046003 (2015).
[3] T Skóra, F Vaghefikia, J Fitter, S Kondrat, Macromolecular crowding: How shape and interactions affect diffusion, J. Phys. Chem. B 124, 7537 (2020).
[4] E Słyk, T Skóra, S Kondrat, How macromolecules softness affects diffusion under crowding, Soft Matter 18, 5366 (2022).
[5] T Skóra, MN Popescu, S Kondrat, Conformation-changing enzymes and macromolecular crowding, Phys. Chem. Chem. Phys. 23, 9065 (2021).
[6] T Skóra, M Janssen, A Carlson, S Kondrat, Crowding-controlled divalent binding (to submit).
Svyatoslav Kondrat: How intracellular-like macromolecular crowding affects diffusion and reactions
Diffusion and reactions are central to understanding life. However, studies often focus on dilute systems, while the interior of living cells is crowded with macromolecules that occupy about 20 % to 40 % of the cell volume, affecting virtually all intracellular processes [1]. In this talk, I will mainly focus on diffusion, emphasising the effects significant to crowded intracellular environments, such as polydispersity of crowders [2], macromolecular shapes, interactions [3], and softness [4]. We will also briefly discuss how reactions proceed under crowding, paying particular attention to enzymatic reactions [5] and the cooperativity of divalent binding [6].
Published Oct. 17, 2022 5:01 PM
- Last modified Oct. 17, 2022 5:01 PM