Guest lectures and seminars - Page 14
This is a half-day online workshop on the numerics and theory of conservation laws and fluid equations. Abstracts and Zoom link can be found here.
The Section 4 seminar for the Autumn of 2023 will be held on Mondays at 10:15–12:00 (see the schedule)
The Deep learning seminar will be held on Thursdays at 10:15–12:00. Please register to this mailing list if you would like updates.
Fluid efflux from the brain plays an important role in solute waste clearance. Current experimental approaches provide little spatial information or data collection is limited due to short duration or low frequency of sampling. One approach shows tracer efflux to be independent of molecular size, indicating bulk flow, yet also decelerating like simple membrane diffusion. In an apparent contradiction to this report, other studies point to tracer efflux acceleration following infusions. In this talk, I will share a stylized advection-diffusion model for clearance of waste, which reconciles the apparent contradiction, and discuss methods to validate it with novel MRI data. Being stylized, it is also simple enough to permit a dimensional analysis which indicates that clearance of waste from the brain is governed by three dimensionless quantities including a potential bottle-neck for clearance due to transport across the surface membranes.