Guest lectures and seminars - Page 40

Abstract: I present the electrophoretic transport phenomenon of spherical soft particles. Electrophoresis is one of the important electrokinetic techniques, which is often used to characterize, and separation of colloids.  It is commonly used as a separation technique and often used in the separation of DNA, protein molecules, serum to identify paraproteins, etc. Electrophoretic transport phenomenon is also used to understand the electric properties of several bioparticles including virus, bacteria, humic cells and macromolecules and may be used to understand the transport of cargo vessel in treatments of various diseases, e.g., cancer, inflammation, multiple myeloma, rental pathological disorders and macroglobulinemia, etc. Thus, the proper understanding of the electrophoretic transport of soft particles is important to understand the characteristics features of various bio-colloids and macromolecules, which can be viewed as soft particles. In this talk, I will present some of the existing simplified models for electrophoretic transport of soft particles. In addition, I have further extended it for the real situation, considering the effect of pH-dependent charge densities of the inner core and peripheral soft polymeric layer, effect of hydrodynamic slip length of the hydrophobic core surface, etc. 

Hybrid format via Zoom possible on demand (contact timokoch at uio.no)

I present a simple, efficient, three dimensional, time dependent model for bone regeneration in the presence of porous scaffolds to bridge critical size bone defects. The essential processes are an interplay between the mechanical and biological environment which we model by a coupled system of PDEs and ODEs. The mechanical environment is represented by a linear elastic equation and the biological environment through reaction-diffusion equations as well as as logistic ODEs, modelling signalling molecules and cells/bone respectively. Material properties are incorporated using homogenized quantities not resolving any scaffold microstructure. This makes the model efficient in computations, thus suitable as a forward equation in optimization algorithms and opening up the possibility of patient specific scaffold design and this model is used as a PDE constraint for the optimization of polymer scaffold porosities. Our numerical findings show that our model for example recovers and quantifies clinically relevant stress shielding effects that appear in vivo due to external fixation of the scaffold at the defect site.

This talk is part of the Mechanics Lunch Seminar series. Bring-your-own-lunch and lots of questions.