Recent publications - Department of Pharmaceutical Biosciences

• Karlsson, Cecilia; Johnsen, Line Kristin; Greasley, Peter; Retterstøl, Kjetil; Hedberg, Jonatan & Hall, Martin [Show all 18 contributors for this article] (2024). Gastric Bypass vs Diet and Cardiovascular Risk FactorsA Nonrandomized Controlled Trial. JAMA Surgery. ISSN 2168-6254. doi: 10.1001/jamasurg.2024.2162.
• Faraj, Pari; Haslemo, Tore; Tran, Jenny Phung; Stingl, Julia; Molden, Espen & Hole, Kristine (2024). Combined effect of CYP2C19 and CYP2D6 genotypes on escitalopram serum concentration and its metabolic ratio in a European patient population. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.16156.
• Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg & Rollag, Halvor [Show all 14 contributors for this article] (2024). Cellular immunity against cytomegalovirus and risk of infection after kidney transplantation. Frontiers in Immunology. ISSN 1664-3224. 15. doi: 10.3389/fimmu.2024.1414830.
• Lindahl, Jørn Petter Hanto; Åsberg, Anders; Heldal, Kristian; Jenssen, Trond; Dörje, Christina & Skauby, Morten Heier [Show all 7 contributors for this article] (2024). Long-term Outcomes After Kidney Transplantation From DBD Donors Aged 70 y and Older. Transplantation direct. ISSN 2373-8731. 10(7). doi: 10.1097/TXD.0000000000001660.
• Nguyen, Nga; Fashing, Peter J.; Trosvik, Pål; Stenseth, Nils Christian & de Muinck, Eric (2024). A Quantitative Comparison of Patterns of Play and Conflict in Nature Preschool and Traditional Preschool Children in Norway. International Journal of Early Childhood. ISSN 0020-7187. doi: 10.1007/s13158-024-00394-1.
• Olsen, Thomas; Elshorbagy, Amany; Stolt, Emma Theresia Kjelland; Åsberg, Anders; Zare, Hasse Khiabani & Bastani, Nasser Ezzatkhah [Show all 9 contributors for this article] (2024). Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study. Amino Acids. ISSN 0939-4451. 56. doi: 10.1007/s00726-024-03398-2.
• Gjøen, Tor; Ruyter, Bente Synnøve & Østbye, Tone-Kari K (2024). Effects of eicosapentaneoic acid on innate immune responses in an Atlantic salmon kidney cell line in vitro. PLOS ONE. ISSN 1932-6203. 19(5), p. 1–20. doi: 10.1371/journal.pone.0302286. Full text in Research Archive
• Mikaelsen, Helena Zaitzow; Ulla, Ingeborg Hjalland; Karimi, David; Mathiesen, Liv; Viktil, Kirsten Kilvik & Syversen, Malin Olsen [Show all 14 contributors for this article] (2024). Medication Discrepancies in Hospitalised Medical Patients – Status After a Decade With Targeted Medication Reconciliation Measures, a Cross-sectional Multicenter Study. Health Services Insights (HSI Journal). ISSN 1178-6329. 17. doi: 10.1177/11786329241254202.
• Rostami, Sina; Rounge, Trine Ballestad; Pestarino, Luca; Lyle, Robert; Fortner, Renée Turzanski & Haaland, Øystein Ariansen [Show all 10 contributors for this article] (2024). Differential levels of circulating RNAs prior to endometrial cancer diagnosis. International Journal of Cancer. ISSN 0020-7136. doi: 10.1002/ijc.34951.
• Tal, Tamara; Myhre, Oddvar; Fritsche, Ellen; Rüegg, Joëlle; Craenen, Kai & Aiello-Holden, Kiara [Show all 34 contributors for this article] (2024). New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project. Frontiers in Toxicology. 6. doi: 10.3389/ftox.2024.1359507. Full text in Research Archive
• Kvitne, Kine Eide; Hjelmesæth, Jøran Sture; Hovd, Markus; Sandbu, Rune; Johnson, Line Kristin & Andersson, Shalini [Show all 11 contributors for this article] (2024). Oral Drug Dosing After Gastric Bypass and Diet-Induced Weight Loss: Simpler Than We Think? Lessons Learned From the COCKTAIL Study. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. doi: 10.1002/cpt.3307.
• Costanzi, Jean-Marc; Stosic, Milan; Løvestad, Alexander; Ambur, Ole Herman; Rounge, Trine Ballestad & Christiansen, Irene Kraus (2024). Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples. Journal of Medical Virology. ISSN 0146-6615. 96(5), p. 1–10. doi: 10.1002/jmv.29641.
• Stevanovic, Stanislava; Dalmao-Fernandez, Andrea; Mohamed, Derya; Nyman, Tuula Anneli; Kostovski, Emil & Iversen, Per Ole [Show all 11 contributors for this article] (2024). Time-dependent reduction in oxidative capacity among cultured myotubes from spinal cord injured individuals. Acta Physiologica. ISSN 1748-1708. doi: 10.1111/apha.14156.
• Ponthier, Laure; Amutmizguine, Julie; Franck, Benedicte; Åsberg, Anders; Ovetchkine, Philippe & Destere, Alexandre [Show all 9 contributors for this article] (2024). Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning. Clinical Pharmacokinetics. ISSN 0312-5963. 63(4), p. 539–550. doi: 10.1007/s40262-024-01362-7.
• Helanterä, Ilkka; Dörje, Christina; Ortiz, Fernanda; Reisæter, Anna Varberg; Hammarström, Clara Louise & Lauronen, Jouni [Show all 11 contributors for this article] (2024). Very Low Frequency of Pathological Findings in One-year Protocol Biopsies of Uneventful Standard Risk Kidney Transplant Recipients: Results from the Nordic Protocol Biopsy Study. Transplantation direct. ISSN 2373-8731. 10(5). doi: 10.1097/TXD.0000000000001621.
• Ponthier, Laure; Autmizguine, Julie; Franck, Benedicte; Åsberg, Anders; Ovetchkine, Philippe & Destere, Alexandre [Show all 9 contributors for this article] (2024). Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-024-01362-7.
• Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Grafinger, Katharina Elisabeth; Huestis, Marilyn A. & Øiestad, Åse Marit Leere (2024). Metabolite markers for three synthetic tryptamines N-ethyl-N-propyltryptamine, 4-hydroxy-N-ethyl-N-propyltryptamine, and 5-methoxy-N-ethyl-N-propyltryptamine. Drug Testing and Analysis. ISSN 1942-7603. p. 1–14. doi: 10.1002/dta.3668.
• Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Størset, Elisabet; Lenk, Hasan Çağın; O'Connell, Kevin S. & Kringen, Marianne K. [Show all 8 contributors for this article] (2024). Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine. Clinical and Translational Science (CTS). ISSN 1752-8054. 17(2). doi: 10.1111/cts.13743.
• Aizenshtadt, Aleksandra; Wang, Chencheng; Abadpour, Shadab; Menezes, Pedro Duarte; Wilhelmsen, Ingrid & Dalmao-Fernandez, Andrea [Show all 15 contributors for this article] (2024). Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver. Advanced Healthcare Materials. ISSN 2192-2640. doi: 10.1002/adhm.202303785.
• Lund, Jenny; Lähteenmäki, Emilia; Eklund, Tiia; Bakke, Hege Gilbø; Thoresen, G. Hege & Pirinen, Eija [Show all 9 contributors for this article] (2024). Human HDL subclasses modulate energy metabolism in skeletal muscle cells. Journal of Lipid Research. ISSN 0022-2275. 65(1). doi: 10.1016/j.jlr.2023.100481.
• Geiseler, Samuel Jakob; Hadzic, Alena; Lambertus, Marvin; Forbord, Karl Martin; Sajedi, Ghazal & Liesz, Arthur [Show all 7 contributors for this article] (2024). L-Lactate Treatment at 24 h and 48 h after Acute Experimental Stroke Is Neuroprotective via Activation of the L-Lactate Receptor HCA<inf>1</inf>. International Journal of Molecular Sciences. ISSN 1661-6596. 25(2). doi: 10.3390/ijms25021232.
• Nordengen, Kaja & Morland, Cecilie (2024). From Synaptic Physiology to Synaptic Pathology: The Enigma of α-Synuclein. International Journal of Molecular Sciences. ISSN 1661-6596. 25(2). doi: 10.3390/ijms25020986.
• De las Cuevas, Carlos; Sanz, Emilio J.; Gross, Jason A.; Correll, Christoph U.; Verdoux, Hélène & Lally, John [Show all 14 contributors for this article] (2024). Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.11.010.
• Mertes, Verena; Saragliadis, Athanasios; Mascherin, E; Tysvær, Ellen-Beate; Roos, Norbert & Linke, Dirk [Show all 7 contributors for this article] (2024). Recombinant expression of Yersinia ruckeri outer membrane proteins in Escherichia coli extracellular vesicles. Protein Expression and Purification. ISSN 1046-5928. 215. doi: 10.1016/j.pep.2023.106409. Full text in Research Archive
• Ruan, Can-Jun; Olmos, Ismael; Ricciardi, Carina; Schoretsanitis, Georgios; Vincent, Philippe D. & Anıl Yağcıoğlu, A. Elif [Show all 27 contributors for this article] (2024). Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients: A literature review and a case series of 17 patients from 3 studies. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.07.002.
• Schoretsanitis, Georgios; Anıl Yağcıoğlu, A. Elif; Ruan, Can-Jun; Eap, Chin B.; Molden, Espen & Baptista, Trino [Show all 24 contributors for this article] (2024). Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition. Schizophrenia Research. ISSN 0920-9964. doi: 10.1016/j.schres.2023.05.010.
• Sarjomaa, Marjut Anneli; Zhang, Chi; Tveten, Yngvar; Kersten, Hege; Reiso, Harald & Eikeland, Randi [Show all 14 contributors for this article] (2024). Risk factors for SARS-CoV-2 infection: A test-negative case-control study with additional population controls in Norway. BMJ Open. ISSN 2044-6055. 14(1), p. 1–11. doi: 10.1136/bmjopen-2023-073766. Full text in Research Archive Show summary

  Objectives This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an additional prepandemic population control group. Design and setting Test-negative design (TND), multicentre case–control study with additional population controls in South-Eastern Norway. Participants Adults who underwent SARS-CoV-2 PCR testing between February and December 2020. PCR-positive cases, PCR-negative controls and additional age-matched population controls. Primary outcome measures The associations between various risk factors based on self- reported questionnaire and SARS-CoV-2 infection comparing PCR-positive cases and PCR-negative controls. Using subgroup analysis, the risk factors for both PCR-positive and PCR-negative participants were compared with a population control group. Results In total, 400 PCR-positive cases, 719 PCR-negative controls and 14 509 population controls were included. Male sex was associated with the risk of SARS-CoV-2 infection only in the TND study (OR 1.9, 95% CI 1.4 to 2.6), but not when PCR-positive cases were compared with population controls (OR 1.2, 95% CI 0.9. to 1.5). Some factors were positively (asthma, wood heating) or negatively (hypertension) associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but lacked convincing association in the TND study. Smoking was negatively associated with the risk of SARS-CoV-2 infection in both analyses (OR 0.5, 95% CI 0.3 to 0.8 and OR 0.6, 95% CI 0.4 to 0.8). Conclusions Male sex was a possible risk factor for SARS-CoV-2 infection only in the TND study, whereas smoking was negatively associated with SARS-CoV-2 infection in both the TND study and when using population controls. Several factors were associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but not in the TND study, highlighting the strength of combining case–control study designs during the pandemic.

• Krapf, Solveig; Lund, Jenny; Bakke, Hege Gilbø; Nyman, Tuula Anneli; Bartesaghi, Stefano & Peng, Xiao-Rong [Show all 9 contributors for this article] (2023). SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation . Metabolism Open. ISSN 2589-9368. 18. doi: 10.1016/j.metop.2023.100234. Full text in Research Archive
• Eide, Per Kristian; Lashkarivand, Aslan; Pripp, Are Hugo; Valnes, Lars Magnus; Hovd, Markus & Ringstad, Geir [Show all 8 contributors for this article] (2023). Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation. Brain Communications. ISSN 2632-1297. 5(6). doi: 10.1093/braincomms/fcad343. Full text in Research Archive
• Forbord, Karl Martin; Okla, Meshail; Lunde, Ngoc Nguyen; Bosnjak, Tatjana; Arnekleiv, Guro Lorvik & Hesselson, Daniel [Show all 11 contributors for this article] (2023). The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice. Cells. ISSN 2073-4409. 13(1). doi: 10.3390/cells13010036. Full text in Research Archive Show summary

  Legumain is a lysosomal cysteine protease that has been implicated in an increasing amount of physiological and pathophysiological processes. However, the upstream mechanisms regulating the expression and function of legumain are not well understood. Here, we provide in vitro and in vivo data showing that vitamin D3 (VD3) enhances legumain expression and function. In turn, legumain alters VD3 bioavailability, possibly through proteolytic cleavage of vitamin D binding protein (VDBP). Active VD3 (1,25(OH)2D3) increased legumain expression, activity, and secretion in osteogenic cultures of human bone marrow stromal cells. Upregulation of legumain was also observed in vivo, evidenced by increased legumain mRNA in the liver and spleen, as well as increased legumain activity in kidneys from wild-type mice treated with 25(OH)D3 (50 µg/kg, subcutaneously) for 8 days compared to a control. In addition, the serum level of legumain was also increased. We further showed that active legumain cleaved purified VDBP (55 kDa) in vitro, forming a 45 kDa fragment. In vivo, no VDBP cleavage was found in kidneys or liver from legumain-deficient mice (Lgmn−/−), whereas VDBP was cleaved in wild-type control mice (Lgmn+/+). Finally, legumain deficiency resulted in increased plasma levels of 25(OH)D3 and total VD3 and altered expression of key renal enzymes involved in VD3 metabolism (CYP24A1 and CYP27B1). In conclusion, a regulatory interplay between VD3 and legumain is suggested.

• Lunde, Ngoc Nguyen; Osoble, Nimo Mukhtar Mohamud; Dalmao-Fernandez, Andrea; Lukacs, Alfreda Serwah; Jafari, Abbas & Singh, Sachin [Show all 10 contributors for this article] (2023). Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism. Biomedicines. 11:2908(11), p. 1–20. doi: 10.3390/biomedicines11112908. Full text in Research Archive
• Cho, Bennet S.; Fligor, Scott C.; Fell, Gillian L.; Secor, Jordan D.; Tsikis, Savas T. & Pan, Amy [Show all 16 contributors for this article] (2023). A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis. PLOS ONE. ISSN 1932-6203. 18(12). doi: 10.1371/journal.pone.0295244. Full text in Research Archive
• Strømmen, Ruth Cecilie; Godang, Kristin; Finnes, Trine Elisabeth; Smerud, Knut Terje; Reisæter, Anna Varberg & Hartmann, Anders [Show all 9 contributors for this article] (2023). Trabecular Bone Score Improves Early After Successful Kidney Transplantation Irrespective of Antiresorptive Therapy and Changes in Bone Mineral Density. Transplantation direct. ISSN 2373-8731. 10(1). doi: 10.1097/TXD.0000000000001566. Full text in Research Archive
• Kamenova, Stefaniya; de Muinck, Eric; Veiberg, Vebjørn; Utsi, Tove Hilde Ågnes; Steyaert, Sam & Albon, Steve [Show all 8 contributors for this article] (2023). Gut microbiome biogeography in reindeer supersedes millennia of ecological and evolutionary separation. FEMS Microbiology Ecology. ISSN 0168-6496. 99(12). doi: 10.1093/femsec/fiad157. Full text in Research Archive
• Carril Leiva, Gabriela Paz; Winther-Larsen, Hanne Cecilie; Løvoll, Marie Therese & Sørum, Henning (2023). Cohabitation of Piscirickettsia salmonis genogroups (LF-89 and EM-90): synergistic effect on growth dynamics. Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 13. doi: 10.3389/fcimb.2023.1253577.
• Kvitne, Kine Eide; Hovd, Markus; Johnsen, Line Kristin; Wegler, Christine; Karlsson, Cecilia & Artursson, Per [Show all 14 contributors for this article] (2023). Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals. Clinical Pharmacokinetics. ISSN 0312-5963. doi: 10.1007/s40262-023-01320-9. Full text in Research Archive
• Hole, Kristine; Gangsø, Sofie; Jensstuen, Åse Tonette; Ormøy, Hanne Holte; Paulsen, Maren & Molden, Espen [Show all 7 contributors for this article] (2023). Effect of CYP2D6 genotype on duloxetine serum concentration. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 134(1), p. 186–192. doi: 10.1111/bcpt.13954. Full text in Research Archive
• Mathiesen, Liv & Skovlund, Eva (2023). Avbrutte tidsserieanalyser. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(14). doi: 10.4045/tidsskr.23.0559. Full text in Research Archive
• Rajalingam, Dhaksshaginy; Boix, Fernando; Khoder, Ala Zaim; Andersen, Jannike Mørch & Paulsen, Ragnhild Elisabeth Heimtun (2023). Distribution of morphine and methadone to the brain in a developmental chicken embryo model. Toxicology and Applied Pharmacology. ISSN 0041-008X. 479. doi: 10.1016/j.taap.2023.116731. Full text in Research Archive
• Irshad, Zehra; Lund, Jenny; Sillars, Anne; Løvsletten, Nils Gunnar; Gharanei, Seley & Salt, Ian P. [Show all 11 contributors for this article] (2023). The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. The FASEB Journal. ISSN 0892-6638. 37(11), p. 1–20. doi: 10.1096/fj.202300960RR. Full text in Research Archive
• Wæhler, Hallvard Austin; Labba, Nils-Anders Johannes; Paulsen, Ragnhild Elisabeth Heimtun; Sandve, Geir Kjetil Ferkingstad & Eskeland, Ragnhild (2023). ANDA: an open-source tool for automated image analysis of in vitro neuronal cells. BMC Neuroscience. ISSN 1471-2202. 24(1), p. 1–11. doi: 10.1186/s12868-023-00826-z.
• Desalegn, Anteneh Assefa; van der Ent, Wietske; Lenters, Virissa Claire; Torcelino-Iszatt, Nina Louise; Stigum, Hein & Lyche, Jan Ludvig [Show all 10 contributors for this article] (2023). Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies. Environment International. ISSN 0160-4120. 181. doi: 10.1016/j.envint.2023.108271. Full text in Research Archive
• de Leon, Jose; Schoretsanitis, Georgios; Smith, Robert Løvsletten; Molden, Espen; Solismaa, Anssi & Seppälä, Niko [Show all 104 contributors for this article] (2023). An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels. Psiquiatría Biológica. ISSN 1696-9138. 30(3). doi: 10.1016/j.psiq.2023.100415.
• Bakkagloglu, Seven A; Vidal, Enrico; Bonthuis, Marjolein; Neto, Gisela; Paripovic, Dusan & Åsberg, Anders [Show all 12 contributors for this article] (2023). European chronic kidney disease registries for children not on kidney replacement therapy: tools for improving health systems and patient-centred outcomes. Clinical Kidney Journal (CKJ). ISSN 2048-8505. 16(11), p. 1980–1985. doi: 10.1093/ckj/sfad204. Full text in Research Archive
• Sahai-Hernandez, Pankaj; Pouget, Claire; Eyal, Shai; Svoboda, Ondrej; Chacon, Jose & Grimm, Lin [Show all 8 contributors for this article] (2023). Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. eLIFE. ISSN 2050-084X. 12. doi: 10.7554/eLife.58300. Full text in Research Archive
• Vethe, Nils Tore; Åsberg, Anders; Andersen, Anders Mikal; Skauby, Ragnhild Kristine Heier; Bergan, Stein & Midtvedt, Karsten (2023). Clinical performance of volumetric finger-prick sampling for the monitoring of tacrolimus, creatinine and haemoglobin in kidney transplant recipients. British Journal of Clinical Pharmacology. ISSN 0306-5251. 89(12), p. 3690–3701. doi: 10.1111/bcp.15870. Full text in Research Archive
• Birkeland, Einar Elvbakken; Ferrero, Giulio; Pardini, Barbara; Umu, Sinan Ugur; Tarallo, Sonia & Bulfamante, Sara [Show all 10 contributors for this article] (2023). Profiling small RNAs in fecal immunochemical tests: is it possible? Molecular Cancer. ISSN 1476-4598. 22:161(1), p. 1–7. doi: 10.1186/s12943-023-01869-w. Full text in Research Archive Show summary

  Fecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. Colorectal cancer (CRC) screening based on the fecal immunochemical test (FIT) is an effective tool for prevention of cancer development. However, due to the poor sensitivity of FIT especially for premalignant lesions, there is a need for implementation of complementary tests. Improving the identification of individuals who would benefit from further investigation with colonoscopy using molecular analysis, such as miRNA profiling of FIT samples, would be ideal due to their widespread use. In the present study, we assessed the feasibility of applying small RNA sequencing to measure human miRNAs in FIT leftover buffer in samples from two European screening populations. We showed robust detection of miRNAs with profiles similar to those obtained from specimens sampled using the established protocol of RNA stabilizing buffers, or in long-term archived samples. Detected miRNAs exhibited differential abundances for CRC, advanced adenoma, and control samples that were consistent for FIT and RNA-stabilizing buffers. Interestingly, the sequencing data also allowed for concomitant evaluation of small RNA-based microbial profiles. We demonstrated that it is possible to explore the human miRNome in FIT leftover samples across populations and envision that the analysis of small RNA biomarkers can complement the FIT in large scale screening settings.

• Geiseler, Samuel Jakob; Phan, Kimberly Dungdung; Brox, Camilla; Nguyen, Teresa Dang; Tartanoglu, Can Hicabi & Doosje, Hanne Lise [Show all 9 contributors for this article] (2023). Pre-stroke exercise does not reduce atrophy in healthy young adult mice. Neuroscience Letters. ISSN 0304-3940. 814. doi: 10.1016/j.neulet.2023.137447. Full text in Research Archive
• Fløde, Mari; Hermann, Monica; Haugstvedt, Anne; Søfteland, Eirik; Igland, Jannicke & Åsberg, Anders [Show all 8 contributors for this article] (2023). High number of hypoglycaemic episodes identified by CGM among home-dwelling older people with diabetes: an observational study in Norway. BMC Endocrine Disorders. ISSN 1472-6823. 23. doi: 10.1186/s12902-023-01472-6. Full text in Research Archive
• Kared, Hassen; Alirezaylavasani, Amin; Lund, Kathrine Persgård; Chopra, Adity; Tietze, Lisa & de Matos Kasahara, Taissa [Show all 17 contributors for this article] (2023). Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients. EBioMedicine. ISSN 2352-3964. 97. doi: 10.1016/j.ebiom.2023.104833. Full text in Research Archive
• Øderud, Tone; Boysen, Elin Sundby; Strisland, Frode; Dahl, Inger-Lise; Bull, Emilie Meyer & Hassel, Bjørnar (2023). Identifying pain and distress in non-verbal persons with intellectual disability: Professional caregivers' and parents' attitudes towards using wearable sensors. Technology and Disability. ISSN 1055-4181. 35(3), p. 207–216. doi: 10.3233/TAD-220390. Full text in Research Archive
• Rognan, Stine; Jørgensen, Mie Jedig; Mathiesen, Liv; Druedahl, Louise Christine; Lie, Helene Berg & Bengtsson, Kajsa Rebecka [Show all 8 contributors for this article] (2023). ‘The way you talk, do I have a choice?’ Patient narratives of medication decision-making during hospitalization. International Journal of Qualitative Studies on Health and Well-being. ISSN 1748-2623. 18(1). doi: 10.1080/17482631.2023.2250084. Full text in Research Archive
• Bogen, Inger Lise; Boix, Fernando; Andersen, Jannike Mørch; Steinsland, Synne; Nerem, Elisabeth & Mørland, Jørg Gustav (2023). Heroin metabolism in human blood and its impact for the design of an immunotherapeutic approach against heroin effects. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 133(4), p. 418–427. doi: 10.1111/bcpt.13926. Full text in Research Archive
• Hole, Kristine; Haslemo, Tore & Molden, Espen (2023). Impact of CYP2D6 Genotype on Paroxetine Serum Concentration. Therapeutic Drug Monitoring. ISSN 0163-4356. 45(5), p. 683–688. doi: 10.1097/FTD.0000000000001096.
• Umu, Sinan Ugur; Paynter, Vanessa Molin; Trondsen, Håvard; Buschmann, Tilo; Rounge, Trine Ballestad & Peterson, Kevin J. [Show all 7 contributors for this article] (2023). Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine. Cell Genomics. 3:100348(8), p. 1–15. doi: 10.1016/j.xgen.2023.100348. Full text in Research Archive
• Kindem, Ingvild Andrea; Åsberg, Anders; Midtvedt, Karsten & Bjerre, Anna Kristina (2023). Optimizing medication adherence with home-monitoring – A feasibility study using capillary microsampling and mHealth in solid organ-transplanted adolescents. Pediatric Transplantation. ISSN 1397-3142. 27(7). doi: 10.1111/petr.14590. Full text in Research Archive
• Tourasse, Nicolas Jacques; Jolley, Keith A.; Kolstø, Anne-Brit & Økstad, Ole Andreas (2023). Core genome multilocus sequence typing scheme for Bacillus cereus group bacteria. Research in Microbiology. ISSN 0923-2508. 174(6). doi: 10.1016/j.resmic.2023.104050. Full text in Research Archive
• Rumbavicius, Ignas; Rounge, Trine Ballestad & Rognes, Torbjørn (2023). HoCoRT: host contamination removal tool. BMC Bioinformatics. ISSN 1471-2105. 24(1). doi: 10.1186/s12859-023-05492-w. Full text in Research Archive
• Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Soeren & Mollnes, Tom Eirik [Show all 11 contributors for this article] (2023). Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study. Frontiers in Immunology. ISSN 1664-3224. 14. doi: 10.3389/fimmu.2023.1253991. Full text in Research Archive
• Solhaug, Vigdis; Tveito, Marit; Waade, Ragnhild Birkeland; Høiseth, Gudrun; Molden, Espen & Smith, Robert Løvsletten (2023). Impact of age, sex and cytochrome P450 genotype on quetiapine and N-desalkylquetiapine serum concentrations: A study based on real-world data from 8118 patients. British Journal of Clinical Pharmacology. ISSN 0306-5251. doi: 10.1111/bcp.15849. Full text in Research Archive
• Handin, Niklas; Yuan, Di; Ölander, Magnus; Wegler, Christine; Karlsson, Cecilia & Jansson-Löfmark, Rasmus [Show all 10 contributors for this article] (2023). Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis. Computational and Structural Biotechnology Journal. ISSN 2001-0370. 21, p. 4361–4369. doi: 10.1016/j.csbj.2023.08.037. Full text in Research Archive Show summary

  Human liver tissue is composed of heterogeneous mixtures of different cell types and their cellular stoichiometry can provide information on hepatic physiology and disease progression. Deconvolution algorithms for the identification of cell types and their proportions have recently been developed for transcriptomic data. However, no method for the deconvolution of bulk proteomics data has been presented to date. Here, we show that proteomes, which usually contain less data than transcriptomes, can provide useful information for cell type deconvolution using different algorithms. We demonstrate that proteomes from defined mixtures of cell lines, isolated primary liver cells, and human liver biopsies can be deconvoluted with high accuracy. In contrast to transcriptome-based deconvolution, liver tissue proteomes also provided information about extracellular compartments. Using deconvolution of proteomics data from liver biopsies of 56 patients undergoing Roux-en-Y gastric bypass surgery we show that proportions of immune and stellate cells correlate with inflammatory markers and altered composition of extracellular matrix proteins characteristic of early-stage fibrosis. Our results thus demonstrate that proteome deconvolution can be used as a molecular microscope for investigations of the composition of cell types, extracellular compartments, and for exploring cell-type specific pathological events. We anticipate that these findings will allow the refinement of retrospective analyses of the growing number of proteome datasets from various liver disease states and pave the way for AI-supported clinical and preclinical diagnostics.

• Damsa, Crina I.; Henriksen, Lise Toft & Christensen, Hege (2023). Dialogue and Artefacts as Instruments in Peer Group Mentoring and Supervision of Problem-Based Learning in Higher Education, Faculty Peer Group Mentoring in Higher Education - Developing Collegiality through Organised Supportive Collaboration. Springer. ISSN 9783031374579. p. 63–77.
• Kipp, Anne Christina; Marti, Hans Peter; Babickova, Janka; Nakken, Sigrid; Leh, Sabine & Strøm Halden, Thea Anine [Show all 11 contributors for this article] (2023). Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts. BMC Nephrology. ISSN 1471-2369. 24. doi: 10.1186/s12882-023-03294-z. Full text in Research Archive
• Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen & Dietrichs, Erik Sveberg (2023). Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients. EBioMedicine. ISSN 2352-3964. 95. doi: 10.1016/j.ebiom.2023.104779. Full text in Research Archive
• Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Jonsson, Grete; Skadberg, Øyvind & Heldal, Kristian [Show all 7 contributors for this article] (2023). Klotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation. Transplantation direct. ISSN 2373-8731. 9(9). doi: 10.1097/TXD.0000000000001522. Full text in Research Archive
• Skagen, Christine; Løvsletten, Nils Gunnar; Asoawe, Lucia; Al-Karbawi, Zeineb; Rustan, Arild Christian & Thoresen, G. Hege [Show all 7 contributors for this article] (2023). Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes. Journal of Thermal Biology. ISSN 0306-4565. 116. doi: 10.1016/j.jtherbio.2023.103623. Full text in Research Archive Show summary

  Transient potential (TRP) ion channels expressed in primary sensory neurons act as the initial detectors of environmental cold and heat, information which controls muscle energy expenditure. We hypothesize that non-neuronal TRPs have direct cellular responses to thermal exposure, also affecting cellular metabolism. In the present study we show expression of TRPA1, TRPM8 and TRPV1 in rat skeletal muscle and human primary myotubes by qPCR. Effects of TRP activity on metabolism in human myotubes were studied using radiolabeled glucose. FURA-2 was used for Ca2+ imaging. TRPA1, TRPM8 and TRPV1 were expressed at low levels in primary human myotubes and in m. gastrocnemius, m. soleus, and m. trapezius from rat. Activation of TRPA1 by ligustilide resulted in an increased glucose uptake and oxidation in human myotubes, whereas activation of TRPM8 by menthol and icilin significantly decreased glucose uptake and oxidation. Activation of heat sensing TRPV1 by capsaicin had no effect on glucose metabolism. Agonist-induced increases in intracellular Ca2+ levels by ligustilide and icilin in human myotubes confirmed a direct activation of TRPA1 and TRPM8, respectively. The mRNA expression of some genes involved in thermogenesis, i.e. peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), uncoupling protein (UCP) 1 and UCP3, were downregulated in human myotubes following TRPA1 activation, while the mRNA expression of TRPM8 and TRPA1 were downregulated following TRPM8 activation by menthol and icilin, respectively. Cold exposure (18 °C) of cultured myotubes followed by a short recovery period had no effect on glucose uptake and oxidation in the basal situation, however when TRPA1 and TRPM8 channels were chemically inhibited a temperature-induced difference in glucose metabolism was found. In conclusion, mRNA of TRPA1, TRPM8 and TRPV1 are expressed in rat skeletal muscle and human skeletal muscle cells. Modulation of TRPA1 and TRPM8 by chemical agents induced changes in Ca2+ levels and glucose metabolism in human skeletal muscle cells, indicating functional receptors.

• Helvik, Anne-Sofie; Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Kersten, Hege; Dourado, Marcia Cristina Nascimento & Johannessen, Aud (2023). Living with young-onset dementia in the family – a mixed method study. Aging & Mental Health. ISSN 1360-7863. 28(2), p. 254–261. doi: 10.1080/13607863.2023.2243585. Full text in Research Archive
• Åsberg, Anders; Hovd, Markus Herberg; Kjellevold, Stig Arne; Stenehjem, Aud Eldrid; Wien, Tale Norbye & Broch, Lars Ulrik [Show all 15 contributors for this article] (2023). Humoral Response After 6 or More Successive Doses of SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients-Should We Keep Vaccinating? Transplantation. ISSN 0041-1337. 107(10), p. e279–e280. doi: 10.1097/TP.0000000000004732. Full text in Research Archive
• Zosen, Denis; Kondratskaya, Elena; Kaplan Arabaci, Öyküm; Haugen, Fred & Paulsen, Ragnhild Elisabeth Heimtun (2023). Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons. Neurochemistry International. ISSN 0197-0186. 169. doi: 10.1016/j.neuint.2023.105571. Full text in Research Archive Show summary

  Antidepressants are used to treat depression and some anxiety disorders, including use in pregnant patients. The pharmacological actions of these drugs generally determine the uptake and metabolism of a series of neurotransmitters, such as serotonin, norepinephrine, or dopamine, along with an increase in BDNF expression. However, many aspects of antidepressant action remain unknown, particularly whether antidepressants interfere with normal neurodevelopment when taken by pregnant women. In order to reveal cellular and molecular implications crucial to the functioning of pathways related to antidepressant effects, we performed an investigation on neuronally differentiating human SH-SY5Y cells. To our knowledge, this is the first time human SH-SY5Y cells in cultures of purely neuronal cells induced by controlled differentiation with retinoic acid are followed by short-term 48-h exposure to 0.1–10 μM escitalopram or venlafaxine. Treatment with antidepressants (1 μM) did not affect the electrophysiological properties of SH-SY5Y cells. However, the percentage of mature neurons exhibiting voltage-gated sodium currents was substantially higher in cultures pre-treated with either antidepressant. After exposure to escitalopram or venlafaxine, we observed a concentration-dependent increase in activity-dependent BDNF promoter IV activation. The assessment of neurite metrics showed significant down-regulation of neurite outgrowth upon exposure to venlafaxine. Identified changes may represent links to molecular processes of importance to depression and be involved in neurodevelopmental alterations observed in postpartum children exposed to antidepressants antenatally.

• Vinknes, Kathrine Jørgensen; Olsen, Thomas; Zare, Hasse Khiabani; Bastani, Nasser Ezzatkhah; Stolt, Emma Theresia Kjelland & Dahl, Anja Falkenhaug [Show all 11 contributors for this article] (2023). Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study. Diabetes, obesity and metabolism. ISSN 1462-8902. 25(11), p. 3161–3170. doi: 10.1111/dom.15210. Full text in Research Archive
• Blom, Kjersti Benedicte; Kro, Grete Anette Birkeland; Midtvedt, Karsten; Jenssen, Trond; Reisæter, Anna Varberg & Rollag, Halvor [Show all 15 contributors for this article] (2023). Cytomegalovirus High-risk Kidney Transplant Recipients Show No Difference in Long-term Outcomes Following Preemptive Versus Prophylactic Management. Transplantation. ISSN 0041-1337. 107(8), p. 1846–1853. doi: 10.1097/TP.0000000000004615. Full text in Research Archive
• Hjemås, Bodil Jahren; Bøvre, Katrine; Bjerknes, Kathrin; Mathiesen, Liv; Mellingsæter, Marte & Molden, Espen (2023). Implementation of pharmacogenetic testing in medication reviews in a hospital setting. British Journal of Clinical Pharmacology. ISSN 0306-5251. 89(10), p. 3116–3125. doi: 10.1111/bcp.15815. Full text in Research Archive

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• Syversen, Malin Olsen; Glatkauskas, Mikas; Benny, Steffi; Horgen, Kristine; Sedeniussen, Sandra Johanne & Hauge, Monica [Show all 12 contributors for this article] (2024). Medication discrepancies revealed by medication reconciliation after hospital discharge in patients with multiple long-term conditions.
• Glatkauskas, Mikas; Syversen, Malin Olsen; Scott, Michael; Svensberg, Karin; Denstad, Berit Gallefoss & Wibe, Torunn [Show all 7 contributors for this article] (2024). Application of a Human Factors and Systems Engineering Approach to Explore the Hospital to Home transition for patients with multiple long-term conditions.
• Lea, Marianne; Trapnes, Elin; Steen, Hanne & Ødegaard, Nina Bjerketveit (2024). A comprehensive training program on patient-centered tasks for hospital-based clinical pharmacists.
• Wastesson, Jonas W.; Lundby, Carina; Kamgang, Karl-Hermann Sielinou; Lea, Marianne & Denig, Petra (2024). Symposium: Deprescribing: a future strategy to optimize medication use in older adults?
• Vethe, Nils Tore; Andersen, Anders Mikal; Gedde-Dahl, Tobias; Buechner, Jochen & Bergan, Stein (2024). Therapeutic Drug Monitoring of Intravenous Busulfan and Analytical Challenges due to the Drug Formulation Excipient PEG 400: Letter to the Editor. Therapeutic Drug Monitoring. ISSN 0163-4356. 46(3), p. 416–417. doi: 10.1097/FTD.0000000000001209.
• Pivoriunas, Jonas; Engebretsen, Ingrid; Vethe, Nils Tore; Kristiansen, Oscar; Dammen, Toril & Husebye, Einar [Show all 9 contributors for this article] (2024). Statin adherence in coronary outpatients: the relationship between a novel direct method and pharmacy registry data. Show summary

  Introduction An optimal method to assess adherence to statin therapy is needed. We developed a novel blood test to determine adherence to atorvastatin and simvastatin therapy. The relationship between statin adherence measured in blood and long-term adherence is yet to be defined. Purpose To compare statin adherence measured by single blood test with pharmacy registry data: i. the three months period prior to the blood test, and ii. from six months before until six months after the blood test. Methods In a cross-sectional study including 451 patients using either atorvastatin or simvastatin, a spot blood sample was collected median 18 months after a coronary heart disease event. Participants were unaware of the forthcoming statin analyses. Adherence (0 or 1 omitted dose) and reduced adherence, defined as ≥2 consecutively omitted doses of atorvastatin and simvastatin was determined by drug concentration measurements using liquid chromatography - tandem mass spectrometry. Study data was linked to the pharmacy registry. Indirect reduced adherence was defined as statin treatment gap exceeding 90 days. Results Thirty-nine (9%) out of 412 patients had reduced adherence to statins, determined by the novel blood test. Among patients classified as adherent by the blood test, only three (0.7%) had a treatment gap exceeding 90 days during the preceding three months. Correspondingly, of 39 patients with reduced adherence by the blood test, 11 (28%) had treatment gaps exceeding 90 days. The positive agreement between the methods was 96% and the negative agreement 42%. Among patients classified as adherent by the blood test, 21 (5%) had treatment gaps exceeding 90 days from six months before until six months after the blood test. Correspondingly, of 39 patients with reduced adherence by the blood test, 15 (39%) had at least one treatment gap exceeding 90 days. The positive agreement between measurements was 95% and the negative agreement 40%. Conclusions Among coronary patients classified as adherent by the statin blood test, registry data only identified three patients (0.7%) with a treatment gap exceeding 90 days in the three months prior to the blood test. The novel blood test emerges as a promising tool to identify patients adherent to statins, and thus may improve lipid management in clinical practice.

• Røed-Undlien, Henriette; Schultz, Nina Haagenrud; Lunnan, Asbjørn; Husebråten, Inger Marie; Wollmann, Birgit Malene Tovik & Molden, Espen [Show all 7 contributors for this article] (2024). Corrigendum to < IN-VITRO APIXABAN REMOVAL BY CYTOSORB® WHOLE BLOOD ADSORBER. AN EXPERIMENTAL STUDY.> <[Journal of Cardiothoracic and Vascular Anesthesia 36/6 (2024) 1636 – 1644]> (Journal of Cardiothoracic and Vascular Anesthesia (2022) 36(6) (1636–1644), (S1053077022000726), (10.1053/j.jvca.2022.01.038)). Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. doi: 10.1053/j.jvca.2024.03.039.
• Marienborg, Kaja; Økstad, Ole Andreas Løchen; Ambur, Ole Herman & Skaare, Dagfinn (2023). The alginate polymer OligoG alters susceptibility of biofilm-embedded non-typeable Haemophilus influenzae to ampicillin and ciprofloxacin.
• Viktil, Kirsten Kilvik; Kinnear, Moira; Lea, Marianne; Blix, Hege Salvesen & Mathiesen, Liv (2023). Teach the Teachers - Workplace based training in clinical pharmacy using patients as a learning resource.
• Syversen, Malin Olsen; Glatkauskas, Mikas; Lea, Marianne; Benny, Steffi; Horgen, Kristine & Svensberg, Karin [Show all 7 contributors for this article] (2023). Medication discrepancies after a hospital stay in patients with multiple long term conditions.
• Lea, Marianne (2023). Legemiddelsamstemming - hva er status? - resultater fra en multisenterstudie.
• Lea, Marianne (2023). Avdiagnostisering. . [Internet]. Medisinpodden, Diakonhjemmet Sykehusapotek.
• Lea, Marianne (2023). Marcus er som en af de første kommet af med sin adhd-diagnose. [Newspaper]. Kristeligt Dagblad.
• Lea, Marianne (2023). Nå skal de fjerne ADHD-diagnoser i Sverige. Bør vi følge etter? . [Newspaper]. Morgenbladet.
• Lea, Marianne (2023). Deprescribing and dediagnosing.The “Beito lecture”. .
• Uppheim, Espen; Viktil, Kirsten Kilvik & Brun, Johan Gorgas (2023). Evaluering av pasientinformasjon om antirevmatiske legemidler. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 8, p. 44–45.
• Økstad, Ole Andreas (2023). The dynamic trio - the good, the bad and the ugly.
• Økstad, Ole Andreas (2023). Reversing carbapenem resistance in Gram-negative pathogens - Preclinical development of the modular synthetic metallo-β-lactamase inhibitor APC148.
• Chau, Khac Thanh Phong & Haugen, Fred (2023). Night Work in Cold Environment.
• Ingelman-Sundberg, Magnus; Jukic, Marin; Bråten, Line Skute; Kringen, Marianne K. & Molden, Espen (2023). What is the Current Clinical Impact of the CYP2CTG Haplotype? Clinical Pharmacology and Therapeutics. ISSN 0009-9236. doi: 10.1002/cpt.3094.
• Rounge, Trine Ballestad (2023). Building epigenetic clocks for estimating accelerating aging in patients with testicular cancer treated with cisplatin-based chemotherapy.
• Lauritzen, Trine; Munkhaugen, John; Peersen, Kari; Andersen, Anders Mikal; Bergan, Stein & Husebye, Einar [Show all 7 contributors for this article] (2023). Atorvastatin lactonization is associated with statin-dependent muscular side effects in patient with coronary heart disease .
• Subramani, Saranya & Winther-Larsen, Hanne Cecilie (2023). Identification of Novel Vaccine Candidates against Piscirikettsiosis.
• Mertes, Verena; Saragliadis, Athanasios; Mascherin, E; Antenucci, Fabio; Bojesen, Anders Miki & Colquhoun, Duncan John [Show all 8 contributors for this article] (2023). Characterization of bacterial extracellular vesicles A versatile tool for potential vaccine application in aquaculture.
• Winther-Larsen, Hanne Cecilie; Langlete, Petter & Krabberød, Anders Kristian (2023). Loading cargo and messenging by bacterial extracellular vesicles.
• Ambur, Ole Herman; Skaare, Dagfinn & Økstad, Ole Andreas Løchen (2023). Alginate polymer alters susceptibility of biofilm-embedded non-typable Haemophilus influenzae .
• Gripheim, Janne Marlene; Åsberg, Anders; Hagness, Morten; Heldal, Kristian & Midtvedt, Karsten (2023). Nyretransplantasjon – en pågående suksesshistorie. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(11). doi: 10.4045/tidsskr.23.0383.
• Simonsen, Gunnar Skov; Blix, Hege Salvesen; Helgesen, Kari Marie Olli & Urdahl, Anne Margrete (2023). NORM/NORM-VET 2022, Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway. NORM/Veterinærinstituttet. ISSN 1502-2307.

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